Monday, January 15, 2007

Platelet Rich Plasma Inhibits Demineralized Bone Matrix

In the study outlined below, it is clear that PRP inhibits bone matrix formation. this is consistent with previous reports. Perhaps, PRP is not useful in enchondral ossification but may be helpful in membranous ossification. Further research is needed.

APEX PRP.com

J Bone Joint Surg Am. 2007 Jan;89(1):139-47. Links
Platelet-rich plasma inhibits demineralized bone matrix-induced bone formation in nude mice.Ranly DM, Lohmann CH, Andreacchio D, Boyan BD, Schwartz Z.

It is unclear whether platelet-rich plasma is a clinically effective adjunct to osteoinductive agents such as demineralized bone matrix. It contains platelet-derived growth factor (PDGF), which decreases osteoinduction by human demineralized bone matrix in nude-mouse muscle, suggesting that platelet-rich plasma may also have a negative impact. This study tested the hypothesis that platelet-rich plasma reduces demineralized bone matrix-induced bone formation and that this effect varies with donor-dependent differences in platelet-rich plasma and demineralized bone matrix. Compared with platelet-poor plasma, platelet-rich plasma preparations exhibited a fourfold increase in the platelet count, a fifteenfold increase in the amount of transforming growth factor-beta, a sixfold increase in the amount of PDGF-BB, a fivefold increase in the amount of PDGF-AA, and a twofold increase in the amount of PDGF-AB. Platelet-rich plasma decreased the osteoinductivity of demineralized bone matrix implanted in immunocom-promised mice, and the activities of both demineralized bone matrix and platelet-rich plasma were donor-dependent. CLINICAL RELEVANCE: Platelet-rich plasma may not be an appropriate adjunct to demineralized bone matrix in some clinical applications.

12 comments:

Anonymous said...

That is what we call a fantastic message board, I never care to read out a complete list of threads but this message board easily earned my attention and believe me, That’s unusual.

[color=#1e60a9][URL=http://www.healthylifestore.co.uk/Equazen]Equazen[/URL] [URL=http://www.healthylifestore.co.uk/St-Clements]St Clements[/URL] [URL=http://www.healthylifestore.co.uk/Red-Bull]Red Bull[/URL] [URL=http://www.healthylifestore.co.uk/Taste-of-Nature]Taste of Nature[/URL] [URL=http://www.healthylifestore.co.uk/Z-Gel]Z-Gel[/URL] [/color]

Anonymous said...

hi, does anyone have a cool place for [url=http://neopets-cheats.us]Neopets Cheats[/url]?

Anonymous said...

Hi Peeps, i would just like to make an say hi to everyone at plateletrichplasma.blogspot.com

Your forum is good! Usually when I visit forums, I just come across rubbish, but this time I was very surprised, finding a informative forum containing good information.

Thanks everyone at plateletrichplasma.blogspot.com and keep the magnificent effort up!!

[color=#1e60a9][URL=http://www.finger-puppets.co.uk/shop]Hand Puppet [/URL] [URL=http://www.contemporary-furnishings.net/Soft-Furnishings-Cushions/c4_15/index.html]Luxury cushions [/URL] [URL=http://www.triciadouglasinteriors.co.uk/interior-design-sheffield] interior design sheffield [/URL] [URL=http://www.finger-puppets.co.uk/shop]Finger Puppet [/URL] [URL=http://www.contemporary-furnishings.net]designer furnishings[/URL] [/color]

Anonymous said...

Thank you, that was extremely valuable and interesting...I will be back again to read more on this topic.

Anonymous said...

Thanks for sharing the link, but unfortunately it seems to be down... Does anybody have a mirror or another source? Please reply to my post if you do!

I would appreciate if a staff member here at plateletrichplasma.blogspot.com could post it.

Thanks,
Charlie

Anonymous said...

Fantastic web site, I hadn't noticed plateletrichplasma.blogspot.com previously in my searches!
Keep up the superb work!

Anonymous said...

Thanks for sharing this link, but unfortunately it seems to be offline... Does anybody have a mirror or another source? Please reply to my post if you do!

I would appreciate if a staff member here at plateletrichplasma.blogspot.com could post it.

Thanks,
Charlie

Anonymous said...

Thanks for sharing this link, but unfortunately it seems to be down... Does anybody have a mirror or another source? Please reply to my post if you do!

I would appreciate if a staff member here at plateletrichplasma.blogspot.com could repost it.

Thanks,
Mark

Anonymous said...

Have you considered the fact that this might work another way? I am wondering if anyone else has come across something
similar in the past? Let me know your thoughts...

Anonymous said...

prareebeewSog
[URL=http://moon.cs.uh.edu/trac/WiserAnalyzer/ticket/16645]online dating sites[/URL]
WepDussybub

Anonymous said...

Hey,

Thanks for sharing the link - but unfortunately it seems to be down? Does anybody here at plateletrichplasma.blogspot.com have a mirror or another source?


Thanks,
William

Anonymous said...

Hi:

I just registered with plateletrichplasma.blogspot.com.
I'm planning to take a look round a tad and hook up with fascinating folks and discover a couple of things.


I'm hoping this message isn't in a bad place. I aplogize if it does.

--------------------

FAUSTO SWANSON
Rail Yard Engineers

HalfDome.TV
Fitness/Sports Medicine Videos (4 million views)

Patient Application Form