Wednesday, January 16, 2008

PRP Stimulates the greatest number of genes

According to recent reports from BEVA 2007, Cornell researchers examined the use of platelet-rich plasma (PRP) in horses with tendon injury, according to Schramme (Schnabel et al., Journal of Orthopedic Research, 2007). "The rationale is that if platelets release considerable growth factors, you could help with the healing of cartilage, tendons, ligaments)," he said.

"This study looked at gene expression patterns, DNA, and collagen content of equine tendon explants cultured (in vitro) with whole blood, plasma, and platelet-rich plasma," he continued. Concentrations of TGF-รข1 and PDGF were higher in PRP-treated tendons, compared to other blood products and bone marrow."

Schramme commented that all blood products stimulate gene expression, PRP seemed to stimulate the greatest number of genes (collagen types II and III, and COMP), with no c with no concomitant (accompanying) increase in molecules of harmful enzymes. "These findings support in vivo (in the live animal) investigation of 100% PRP as an autogenous (generated in the body), patient-side treatment for tendonitis," he noted. "It's another treatment that we need to carefully evaluate in vivo as it continues to come along.

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