Sunday, January 17, 2010

Platelet Rich Plasma JAMA Article

A recently published article by de Vos et al in JAMA has resulted in a flurry of lay press articles declaring platelet rich plasma (PRP) does not work.  Much like the overhype of PRP after Hines Ward was treated just before the Super Bowl last year, this declaration cannot be defended.

In their study, patients with MODERATE achilles tendinopathy did not do better with PRP compared to saline controls.  All patients received eccentric strengthening exercises.  Their data does support the conclusion that PRP is not better than saline but ONLY for moderate tendinopathy (as measured clinically, no imaging data was reported) at six months of follow up.    The authors stated they will be following those patients for a year.  If for some reason, the PRP patients continue to improve and the saline ones do not, there could be a difference at one year.  However, the conclusion could then only be made that PRP works for MODERATE achilles tendinopathy not any other clinical entity.  Patients with SEVERE tendinopathy that has failed eccentric training was not tested in this study.

The authors need to be recognized for completing this study as we need more level one evidence like it to best define how to use PRP.  Soon, we will have more published literature to discuss. 

We still need to define the optimal formulation and dosage of PRP.  No data was collected on the patients with regard to what was actually put into the patient in terms of total platelet concentration and or white blood cell concentration.  Importantly, we also need a better understanding of the mechanisms behind PRP.

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I also read an extensive article / report (published by doctors in Rome in Dec 2009) done on numerous PRP tests done on a number of patients and the results thereof. However, I can't find this report on the net anymore. Do you perhaps know anything about it?
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Anonymous said...

hello all,

I am now a member plateletrichplasma.blogspot.com, I hope this is the right category this ( If my post is in wrong category, move me) so hello again everybody. I am a full time student trying to become a personal trainer in 6 months, lastly I want to lose pounds fast. How can I teach people when I'm not even in shape
[img]http://lose14poundsin14days.com/lose-14-pounds.gif[/img]

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Anonymous said...

Hi all,, thought I would finally sign up to forum although I have been following Peter for a long time on the boards. Well anyway it is nice to now offically be a part of the team and I look forward to participating on the forum.

Regards. William.

Anonymous said...

Hi all,

Firstly thank you all for maintaining this forum. I have actually learnt a lot from it over the last few months, finally decided to join.

Hopefully I wil be able to give back to members as much as I have gained.

scarlet reynolds said...

I came across your blog while searching the internet for Plasma hire websites. Anyway, allow me to give my point of view regarding your topic. Platelet rich plasma is very vital in wound healing. Recent advances have documented that as platelets are activated, they release agents that promote tissue repair, inflammation and angiogenesis.

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