Saturday, April 03, 2010

Mishra Platelet Rich Plasma Classification

Not all platelet rich plasma (PRP) is the same.  In order to be able to compare PRP, I am proposing a new classification system based on the presence or absence of white blood cells, activation status and platelet concentration.  Activation implies the use of thrombin and or calcium to cause the platelets to gel and release their bioactive molecules.  No activation implies in vivo activation by collagen. 

Platelet Concentration:   
A = 5 x baseline or higher
B =  Less than 5 x baseline

Type          White Blood Cells              Activation    

Type 1:       Increased WBCs                  Unactivated

Type 2:       Increased  WBCs                 Activated

Type 3:       Few/None WBCs                 Unactivated

Type 4:       Few/None WBCs                 Activated



Example:
Type 1A PRP:    Formulation with increased WBCs, 5.5x baseline platelets injected in an unactivated fashion.

The system is meant to be simple for now.  Clearly, there are other components to PRP including anticoagulation and buffering.  Importantly, new formulations may arise but for now we need a simple reproducible structure to discuss the different types of PRP.  I hope this represents a start.

AM
Total Tendon

4 comments:

kenmerrimanmd said...

I think that such a classification will be of use in reporting
I personally usuallly use Cascade which is wbc poor <5x and I normallt do not activate it when injecting as opposed to the fibrin clot trick which probably activates it
So I usually use a B3

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Daniela Lima said...

A question: Do you have a reference or publication of this classification, so it can be cited in other articles? Thanks.

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