tag:blogger.com,1999:blog-263215972024-03-13T09:48:27.040-07:00BloodCure from Dare To Be VitalHow to enhance Vitality and the latest information about Regenerative Medicine, Stem Cells, Platelet Rich Plasma and Sports MedicineUnknownnoreply@blogger.comBlogger295125tag:blogger.com,1999:blog-26321597.post-61330831952109895912019-09-22T15:10:00.001-07:002019-09-22T15:10:44.234-07:00Consider Sleep a SuperPower Part 2<h4 style="clear: both; text-align: center;">
<b><a href="http://daretobevital.com/" target="_blank">DareToBeVital.com</a></b></h4>
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What do Tom Brady and Roger Federer have in common? They are both superstar athletes that continue to win even as they enter middle age. They are also bingeing on a legal performance enhancing drug called sleep. Too often we ignore the value of sleep. Don't participate in the stress olympics and brag about how little sleep you get each night. Prioritize sleep. You will be rewarded with improved physical, mental, social and spiritual wellness. You will enjoy more vitality. So, start today and consider sleep a superpower.<br />
<a href="http://daretobevital.com/" target="_blank"><b><br /></b></a>
<a href="http://daretobevital.com/" target="_blank"><b>#DareToBeVital</b></a><br />
<br />Unknownnoreply@blogger.com1tag:blogger.com,1999:blog-26321597.post-77936986662629047272019-09-15T07:55:00.001-07:002019-09-15T07:57:33.522-07:00Sleep is a Superpower #DareToBeVital<iframe allowfullscreen="" frameborder="0" height="270" src="https://www.youtube.com/embed/ZZYcDFV5xe4" width="480"></iframe><br />
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Sleep is fundamental to our Vitality. The video above challenges you to Consider Sleep a Superpower. You can do this by making it a primary priority. Exercising can help burn off energy and help you sleep. Also, optimize your sleep environment by making it dark, cool,and quiet. Learn more at: <a href="http://www.daretobevital.com/" target="_blank">DareToBeVital</a>Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-26321597.post-27550671074186168752019-09-14T09:50:00.001-07:002019-09-14T09:50:34.100-07:00<a href="http://www.daretobevital.com/" target="_blank"><img border="0" height="293" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEh06vuJpgNjV0WfrNImIZAy6PwxnuTV_33-eHl8GVBIcuBbNc9UM9wqofWiN9X_hcp4usrlcPyZSLVruDBSYBUaBJara_laaXal23O8rQapruvo3prTT85pOA5ZVBCUMjTzbhBF/s320/DareToBeVital.png" width="320" /></a><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEh4z5EE7gtWQpHzmdvAucb5TYpelxrPG78hAYx6iUh2RUkWOO9l5dSabOS2xevt1eluokedUEsyrlUfDU9eHKaPWkKDNF3z3ntoN88gUBhcjfxB8XrK7AVlCZygO_V9jl63DJkL/s1600/Campbell+Trophy.png" imageanchor="1"><img border="0" height="223" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEh4z5EE7gtWQpHzmdvAucb5TYpelxrPG78hAYx6iUh2RUkWOO9l5dSabOS2xevt1eluokedUEsyrlUfDU9eHKaPWkKDNF3z3ntoN88gUBhcjfxB8XrK7AVlCZygO_V9jl63DJkL/s320/Campbell+Trophy.png" width="320" /></a><br />
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<b><a href="http://daretovital.com/">DareToVital.com</a> </b>is a movement started by <a href="https://www.linkedin.com/in/allanmishra/" target="_blank"><b>Dr. Allan Mishra</b></a>. Check out the site to learn more about how to enhance your vitality. Dr. Mishra teaches a popular course at Stanford on the topic and has lectured at Google, Stanford's Graduate School of Business (GSB), the University of Michigan and in front of Navy SEALs. <a href="http://www.daretobevital.com/" target="_blank">See videos</a> about how to Pinpoint Your Purpose and Consider Sleep a Superpower. What do you do to enhance your vitality? Please post below. Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-26321597.post-27582053809833363612017-04-04T20:46:00.002-07:002017-04-04T20:46:41.259-07:00CryoTherapy, A Vitality BioHackCryotherapy tanks have become quite popular. In the video below, I explore what it is like to be in one when the temperature plummets to minus 137 degrees. Check it out...<br />
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<iframe allowfullscreen="" frameborder="0" height="315" src="https://www.youtube.com/embed/K6oF6p43USY" width="560"></iframe>Unknownnoreply@blogger.com4tag:blogger.com,1999:blog-26321597.post-52667594459559812942016-09-11T19:07:00.000-07:002016-09-11T19:07:49.550-07:00The Power to Heal Comes from Within<br />
Powerful chemical weapons, also known as drugs, and sophisticated surgical procedures have dominated the practice of medicine for many decades. For at least the last 15 years, maverick researchers and physicians have been exploring biologic alternatives to drugs and surgery. Instead of searching the world for a novel chemical compound or engineering a sleek surgical device, they have looked in an unusual place--inside the body itself. <b>Could it be possible that the power to heal comes from within our own bodies? The answer today is a qualified yes. </b><br />
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Think about it for just a moment. Next time your get a small paper cut, simply observe what happens. You bleed a little. It stops on it own. You put a bandaid on it and magically it heals over the course of less than a week. Similarly, if you sustain a simple fracture, it typically heals on its own with immobilization and a few weeks of time. Your liver is your most amazing regenerative organ. You can literally cut out a lobe of your liver and transplant it into someone else. That missing lobe will then regrow on its own. Skin, bone and liver are tissues that have excellent capacity to self heal. Other tissues need a helping hand. <b>Fortunately, within our own bodies are many tissues that can help heal other tissues</b>. Blood, bone marrow and adipose tissue (also known as Fat) are three examples. <br />
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To begin, let's explore platelet rich plasma, also known as "PRP". PRP is a component of blood that can be prepared using a simple desktop sized centrifuge in about 10 minutes. I have using PRP to treat chronic tennis elbow now for more than a decade with excellent success rates. Multiple studies now confirm the value of PRP in the treatment of this common disorder. A <a href="http://www.ncbi.nlm.nih.gov/pubmed/27268111" target="_blank">recent meta-analysis of randomized controlled trials</a> noted <b>PRP to be "of great clinical significance.</b>" PRP has also been used to treat diabetic foot ulcers, knee arthritis and degenerative disc disease. Overall, there are now more than <a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=platelet+rich+plasma" target="_blank">8600 published studies evaluating the basic science and clinically efficacy of PRP.</a> Importantly, in all of the areas studied, PRP has an excellent safety record. That of course makes sense. PRP is simply a component of your own blood. <br />
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Cancer immunotherapy is another example of using your body to help heal itself. Cancer immunotherapy essentially reprograms your immune system to help fight nasty cancers. Recently published data has found an <a href="http://www.sciencealert.com/researchers-claim-unprecedented-success-treating-cancer-with-t-cells" target="_blank">"unprecedented" 94% of patients with a specific type of blood cancer achieving complete resolution of their symptoms</a>. The technique involves removing your own white blood cells, reprogramming them to attack tumors in the lab and then injecting them back into your body. To quote one researcher, <a href="http://www.sciencealert.com/researchers-claim-unprecedented-success-treating-cancer-with-t-cells" target="_blank">"This is really a revolution."</a><br />
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Finally, a therapy that sounds like it came out of a science fiction or horror movie is just beginning. The idea of parabiosis involves merging the circulation of two animals. The original research was done in young and old rats in 1956. For the details please review a tantalizing paper entitled "Experimental Prolongation of the Life Span (<a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1805858/pdf/bullnyacadmed00383-0015.pdf" target="_blank">Re</a>f 1) When their circulations were connected, the young mice started becoming "old" and the old mice started to appear "young". Something in the blood of young mice was helping reverse the affects of aging in older mice. The coats of the old gray mice were turning brown again. Other research conducted at Stanford suggested young blood could boost brain cell growth in older mice. <a href="https://www.theguardian.com/science/2015/aug/04/can-we-reverse-ageing-process-young-blood-older-people" target="_blank">(Ref </a>2, <a href="http://bigthink.com/laurie-vazquez/can-aging-be-reversed-by-getting-blood-transfusions-from-young-people" target="_blank">Ref </a>3 <a href="http://www.sciencemag.org/news/2016/08/young-blood-antiaging-trial-raises-questions" target="_blank">Ref 4</a>) This research was so intriguing, it led to the development of a <a href="https://clinicaltrials.gov/ct2/show/NCT02256306" target="_blank">clinical trial focused on the transfusion of young blood to older patients with Alzheimer's disease.</a> Silicon Valley tycoons are also helping finance similar "treatments" for middle aged rich people who want to stay young or reverse the affects of aging. A company has even been started and is presently conducting clinical trials. Interestingly, the company is named Ambrosia after the mythologic Greek drink that was supposed to confer longevity or even immortality. <a href="http://www.inc.com/jeff-bercovici/peter-thiel-young-blood.html" target="_blank">Peter Thiel, an iconoclastic venture capitalist </a>, appears to be quite interested in this approach to combating the aging process. This approach is clearly not yet proven but is intriguing. <br />
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If we are seeking transformative solutions to difficult problems, I suggest we look inside. We might just find the power to heal. <br />
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<a href="http://www.allanmishra.com/" target="_blank">Allan Mishra</a><br />
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<br />Unknownnoreply@blogger.com8tag:blogger.com,1999:blog-26321597.post-75733798440774584612016-05-12T10:13:00.000-07:002016-12-08T12:16:22.827-08:00Turmeric for Tendonitis, Arthritis, and Cancer<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiqr_KnfQY69WtE5y0OLxAk1Q04g7GfmVbE3LNQMD7o8godRISAFVNO6cdUVTtEZXZKSUtBVg2F1Cn2PhW9o8KpF4LUJw9dXm97xtHRCRDEIYZGF7Cc-jfPHmp0r9KX0Hw45XD7/s1600/Screen+Shot+2016-05-12+at+8.58.00+AM.png" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"></a><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiiCMsLA27LaIqZER_uX15NUdMwaJO9DvuwZLohveez4TRIjfDtQikvLndTMYpPV1UqraZCEvshHkwC6AE_2L0kBG3hnlf574S4s6L8fJw7ex0A3CGSlJYkkew4PhMyIKfZT066/s1600/Screen+Shot+2016-05-12+at+8.58.00+AM.png" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" height="218" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiiCMsLA27LaIqZER_uX15NUdMwaJO9DvuwZLohveez4TRIjfDtQikvLndTMYpPV1UqraZCEvshHkwC6AE_2L0kBG3hnlf574S4s6L8fJw7ex0A3CGSlJYkkew4PhMyIKfZT066/s320/Screen+Shot+2016-05-12+at+8.58.00+AM.png" width="320" /></a><br />
The golden spice turmeric, commonly found in many tasty Indian dishes, contains an interesting and potentially valuable therapeutic component. Curcumin, found in turmeric, modulates several cellular pathways and has been used as a nutraceutical supplement to combat inflammation. Importantly, turmeric has been found to have a high safety profile. This is consistent with its use for thousands of years in India and China. <br />
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Research studies have shown turmeric can modify tendon inflammatory pathways. (<a href="https://www.ncbi.nlm.nih.gov/pubmed/21669872" target="_blank">Ref</a>) One study found "curcumin can improve the quality of tendon rupture healing, and thus represents a promising strategy in the management of injured tendon tissue." (<a href="https://www.ncbi.nlm.nih.gov/pubmed/26540017" target="_blank">Ref</a>)<br />
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Tumeric / Curcumin may also be of value in the treatment of osteoarthritis by decreasing inflammatory pathways. "Short-term supplementation with curcuminoids attenuates the systemic oxidative stress in patients with osteoarthritis. These antioxidant effects may account for the reported therapuetic effects of curcuminoids in relieving osteoarthritis symptoms. (<a href="https://www.ncbi.nlm.nih.gov/pubmed/25688638" target="_blank">Ref</a>) Some clinical studies suggest using Tumeric / Curcumin may result in better improvements in pain and walking when compared to using chondroitin and glucosamine supplements alone. (<a href="https://www.ncbi.nlm.nih.gov/pubmed/25555891" target="_blank">Ref</a>) Finally, some formulations of curcumin have been specifically found to reduce the pain associated with knee arthritis. (<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244558/" target="_blank">Ref</a>) (See chart below)<br />
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Recently, curcumin has also been studied as a cancer treatment. It has been shown to inhibit a variety of pathways connected to cancer cell growth. It may also enhance the cytotoxic effects of chemotherapy thereby enhancing its efficacy. Much more work needs to be done but these early cancer studies have confirmed cucurmin's excellent safety profile. I started to wonder if we should consider taking curcumin to prevent cancer. <br />
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Bloodcure's take home message for turmeric is to consider it for tendonitis and arthritis symptoms. The data suggest the supplement is safe and it may be a natural way to treat these very common disorders. Consider a dose of 500 mg to 1500 mg per day that contains black pepper extract. The black pepper helps with absorption of the turmeric. <br />
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<b>As always, check with your personal physician prior to initiating any new supplement as each of us is unique.</b><br />
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<a href="http://www.allanmishra.com/" target="_blank">AM</a><br />
<a href="http://www.totaltendon.com/" target="_blank">TotalTendon</a><br />
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<br />Unknownnoreply@blogger.com3tag:blogger.com,1999:blog-26321597.post-8253305477151242542016-02-28T13:25:00.000-08:002016-02-28T18:48:04.580-08:00Leg Power Predicts Brain Power<b><span style="font-size: large;">Save your brain by strengthening your legs.</span></b><br />
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<b>Here are a few bullet points from a recently published <a href="http://www.ncbi.nlm.nih.gov/pubmed/26551663" target="_blank">study by Claire Steves</a> et al from Kings College in London about leg power and brain function. </b><br />
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<b>1. Leg power is correlated with cognition over a 10 year period</b><br />
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<b>2. Leg power also correlated with total gray matter in the brain.</b><br />
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<b>3. Fasting blood glucose and diabetes status were other variables associated with cognition.</b><br />
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<b>So, if you want to maintain your brain function over time, stop eating donuts and get your legs in shape.</b><br />
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One simple program is to walk more often and more vigorously. <br />
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The other is considering starting the <a href="http://www.powerknee.com/" target="_blank"><b>PowerKnee Program</b></a>. This is a simple program that activates your primary leg muscles, stretches your hamstrings and uses an exercise bike to strengthen all of your lower extremity muscles. I have been recommending it to strengthen knees but now the data is clear. <b>Strengthen your knees and you will also strengthen your brain.</b><br />
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<b>The QuadCrunch helps to activate the quadriceps muscle. (From the <a href="http://www.powerknee.com/" target="_blank">PowerKnee Program</a>)</b><br />
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<iframe allowfullscreen="" frameborder="0" height="315" src="https://www.youtube.com/embed/EREKD3bFwCc" width="560"></iframe>
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The results of Steves' study are important because they were conducted in twins over more than a decade. This means that it is more likely that improved leg power results in better cognition because they controlled for genetics in addition to a variety of other factors.<br />
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<a href="http://www.allanmishra.com/" target="_blank">AM</a><br />
<a href="http://www.totaltendon.com/" target="_blank"><b>Total Tendon</b></a>Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-26321597.post-33745159147370385512016-02-24T16:05:00.000-08:002016-02-24T16:05:00.016-08:00Tiger Woods is getting betterCheck out Tiger Woods' swing. It looks like he is feeling a lot better after multiple back surgeries.<br />
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Best of luck for a full recovery. </div>
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Progressing nicely. <a href="https://t.co/HKnnluR1OW">pic.twitter.com/HKnnluR1OW</a></div>
— Tiger Woods (@TigerWoods) <a href="https://twitter.com/TigerWoods/status/702492113188032512">February 24, 2016</a></blockquote>
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Video of my own back surgery.<br />
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<iframe allowfullscreen="" frameborder="0" height="315" src="https://www.youtube.com/embed/W_9YaOLcFAg" width="560"></iframe>
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<a href="http://www.allanmishra.com/" target="_blank">AM</a><br />
<a href="http://www.totaltendon.com/" target="_blank">Total Tendon </a><br />
<script async="" charset="utf-8" src="//platform.twitter.com/widgets.js"></script>Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-26321597.post-86606241022550848772016-02-07T13:07:00.001-08:002016-02-07T13:07:50.648-08:00Signing of the Stars and Coach Jim Harbaugh<b>What I learned from the University of Michigan Signing of the Stars and Coach Jim Harbaugh</b><br />
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<b>by Allan Mishra</b><br />
<b><a href="https://twitter.com/bloodcure" target="_blank">@bloodcure</a></b><br />
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<b>Seek a unique perspective.</b><br />
Harbaugh and his expert production team took a rather mundane event (signing of high school football players) and turned it into an Oscar-like event. The day inspired not only the Michigan football program but the entire university.<br />
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEizsHnnWXMq1uJzpUjsEnEkxPV-_gqfycK2XmIuM5SZvprWiwPDjscRZ2C4Ya9x_kdP3qARHBPvBlbhTUjSYzDRtYONx-8OJZ6dk-h28wFJyWgy1D4BeDRLIqurz7ICda7ND5Bi/s1600/JH+AM.jpg" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" height="320" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEizsHnnWXMq1uJzpUjsEnEkxPV-_gqfycK2XmIuM5SZvprWiwPDjscRZ2C4Ya9x_kdP3qARHBPvBlbhTUjSYzDRtYONx-8OJZ6dk-h28wFJyWgy1D4BeDRLIqurz7ICda7ND5Bi/s320/JH+AM.jpg" width="240" /></a><b>Embrace diversity.</b><br />
The crowd supporting the newly signed Michigan players included Tom Brady, Derek Jeter, Denard Robinson, Jordon Kovacs, Charles Woodson, wrestler Rick Flair, world champion poker player Phil Hellmuth, rap group Migos, Owen Wilson, Vince Vaughn, Coach Mike Ditka, and many others. The collective value of the group to the signees and audience was staggering.<br />
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<b>Sometimes you just have to ask.</b><br />
Former Notre Dame Coach Lou Holtz helped carry the event with excellent one liners. Why did a coach from another school come to a Michigan football event? Simply because Jim Harbaugh asked him. To the new Michigan players Holtz said: "You didn't just make a four year decision, you made a 40 year decision" He understands and articulated how the new players would be part of Michigan for the rest of their lives---a powerful message.<br />
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<b>"Some people think less is more, I believe more is more."---Jim Harbaugh</b><br />
Jim Harbaugh doesn't like meetings and discusses strategy on the field with this players and coaches during marathon four hour practices. We all should have less meetings and execute instead of engaging in perpetual discussion. <br />
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<b>"Those who stay will be champions"-----Coach Bo Schembechler</b><br />
Harbaugh added a corollary to that famous Michigan axiom. "Try hard and you will stay". He has written this above the exit sign from the Michigan locker room. The implication is clear. Work as hard as you can and you will stay. Stay and you will be a champion. Embracing this mindset could help all of us in our chosen professions. <br />
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<b>"Attack each day with an enthusiasm unknown to mankind."---Jim Harbaugh </b><br />
Harbaugh and his team gave a swag bag full of gear emblazoned with his motto to all the presenters. After the star-studded event was over around 1 pm, Harbaugh, true to form, was quoted by the Michigan daily as saying: “We’ll be back to work at 2.30.” Translation---have some fun but then return to the relentless pursuit of being one of the leaders and best. <br />
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<b>Video montage of the event produced by <a href="http://videovision360.com/" target="_blank">VisionVideo360</a></b><br />
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<iframe allowfullscreen="" frameborder="0" height="315" src="https://www.youtube.com/embed/cJ3FlqxUGPg" width="560"></iframe><br />
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<a href="http://www.allanmishra.com/" target="_blank">AM</a><br />
<a href="https://twitter.com/bloodcure" target="_blank">@bloodcure</a><br />
<a href="http://www.totaltendon.com/" target="_blank">TotalTendon</a>Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-26321597.post-81408822970861103552016-01-26T19:54:00.001-08:002016-01-27T08:13:52.937-08:00Platelet Rich Plasma beats Surgery for Tennis Elbow<div style="text-align: justify;">
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<span style="text-align: start;">Treatment of tennis elbow using <b><a href="http://apexprp.com/" target="_blank">platelet rich plasma</a> (PRP) resulted in an average of 83% improvement in pain scores</b> at one year compared to baseline i</span>n a recently published study of 110 patients by Karaduman et al. <span style="text-align: start;"> The surgery group had 46% improvement in pain scores. Mayo elbow scores were also higher in the PRP group. </span>(See graphs below)<span style="text-align: start;"> </span></div>
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<span style="text-align: start;">The study used the <u>Biomet GPS PRP device</u> and the <u>Nirschl surgical technique</u></span></div>
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEguDZe5D9frDmyyBCYclLahm1ppz8VVXffZlgJilwEc-Sazkx56Lhe0ZNIt7dX8j43MJ9oWdIyse9XzAFU3mitqN-JV_p1MJ9Jw5ryvnIqPD9yTEmURUuDcg8KzVjo7bdybifQT/s1600/PRP+vs+Surg.png" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="305" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEguDZe5D9frDmyyBCYclLahm1ppz8VVXffZlgJilwEc-Sazkx56Lhe0ZNIt7dX8j43MJ9oWdIyse9XzAFU3mitqN-JV_p1MJ9Jw5ryvnIqPD9yTEmURUuDcg8KzVjo7bdybifQT/s400/PRP+vs+Surg.png" width="400" /></a></div>
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhTJUpNJ5AFJ56gcxHX8V6WkSy3JkEIKAUiwuz6e5tInEEoYh63fcTgEa_8QjT7SXmhlKggV0B17K1Ro8tClNJlpilewj2yP2NIh9jNB2UB0WcPHnVDVwnikSzHH_7VhSoWdt9R/s1600/Mayo+Elbow.png" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="305" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhTJUpNJ5AFJ56gcxHX8V6WkSy3JkEIKAUiwuz6e5tInEEoYh63fcTgEa_8QjT7SXmhlKggV0B17K1Ro8tClNJlpilewj2yP2NIh9jNB2UB0WcPHnVDVwnikSzHH_7VhSoWdt9R/s400/Mayo+Elbow.png" width="400" /></a></div>
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This is an interesting study comparing the value of PRP versus a commonly recommended surgical procedure. The data suggest PRP is a safe and effective alternative to the much more invasive and expensive surgical procedure.</div>
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<a href="http://www.allanmishra.com/" target="_blank">AM</a></div>
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<a href="https://twitter.com/bloodcure" target="_blank">@bloodcure</a></div>
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<a href="http://www.totaltendon.com/" target="_blank">Total Tendon</a></div>
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See abstract and reference below:</div>
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<div class="abstract svAbstract " data-etype="ab" style="border: 0px; color: #2e2e2e; font-size: 16px; line-height: 23px; margin: 0px; padding: 0px; vertical-align: baseline;">
<h2 class="secHeading" id="authorabs00051" style="border: 0px; clear: both; color: #5c5c5c; font-size: 18px; font-weight: 100; line-height: inherit; margin: 20px 0px 6px; padding: 0px; vertical-align: baseline;">
<span style="font-family: "times" , "times new roman" , serif;"><a href="http://www.sciencedirect.com/science/article/pii/S0972978X15001774" target="_blank">Karaduman et el 2016</a></span></h2>
<h2 class="secHeading" id="authorabs00051" style="border: 0px; clear: both; color: #5c5c5c; font-size: 18px; font-weight: 100; line-height: inherit; margin: 20px 0px 6px; padding: 0px; vertical-align: baseline;">
<span style="line-height: inherit;"><span style="font-family: "times" , "times new roman" , serif;">Abstract</span></span></h2>
<h4 id="absSec_1" style="border: 0px; clear: both; color: #5c5c5c; font-weight: 100; line-height: inherit; margin: 20px 0px 8px; padding: 0px; vertical-align: baseline;">
<span style="font-family: "times" , "times new roman" , serif;">Purpose</span></h4>
<div id="spar0005" style="border: 0px; margin-bottom: 9px; padding: 0px; vertical-align: baseline; word-spacing: -0.15ex;">
<span style="font-family: "times" , "times new roman" , serif;">To compare short and mid-term results in the treatment of chronic elbow tendinosis with platelet-rich plasma (PRP) or Nirschl surgical technique.</span></div>
<h4 id="absSec_2" style="border: 0px; clear: both; color: #5c5c5c; font-weight: 100; line-height: inherit; margin: 20px 0px 8px; padding: 0px; vertical-align: baseline;">
<span style="font-family: "times" , "times new roman" , serif;">Method</span></h4>
<div id="spar0010" style="border: 0px; margin-bottom: 9px; padding: 0px; vertical-align: baseline; word-spacing: -0.15ex;">
<span style="font-family: "times" , "times new roman" , serif;">A retrospective study was conducted on patients with chronic lateral epicondylitis, treated by Nirschl surgical technique (50 elbows) or PRP (60 elbows). Outcome was evaluated with Visual Analog Score (VAS), Mayo Elbow Scores and grip strength measurements.</span></div>
<h4 id="absSec_3" style="border: 0px; clear: both; color: #5c5c5c; font-weight: 100; line-height: inherit; margin: 20px 0px 8px; padding: 0px; vertical-align: baseline;">
<span style="font-family: "times" , "times new roman" , serif;">Results</span></h4>
<div id="spar0015" style="border: 0px; margin-bottom: 9px; padding: 0px; vertical-align: baseline; word-spacing: -0.15ex;">
<span style="font-family: "times" , "times new roman" , serif;">VAS and Mayo Elbow Scores of the PRP group had improved as a mean of 83% (<em style="border: 0px; margin: 0px; padding: 0px; vertical-align: baseline;">p</em> = 0.0001), 74% (<em style="border: 0px; margin: 0px; padding: 0px; vertical-align: baseline;">p</em> = 0.0001) over baseline and 34.2 pounds gain of grip strength.</span></div>
<h4 id="absSec_4" style="border: 0px; clear: both; color: #5c5c5c; font-weight: 100; line-height: inherit; margin: 20px 0px 8px; padding: 0px; vertical-align: baseline;">
<span style="font-family: "times" , "times new roman" , serif;">Conclusion</span></h4>
<div id="spar0020" style="border: 0px; margin-bottom: 9px; padding: 0px; vertical-align: baseline; word-spacing: -0.15ex;">
<span style="font-family: "times" , "times new roman" , serif;">The PRP seems to be better for pain relief and functionality in the short and mid-term periods.</span></div>
</div>
<h2 class="svKeywords" id="kwd_1" style="border: 0px; clear: both; color: #5c5c5c; font-size: 18px; font-weight: 100; line-height: inherit; margin: 20px 0px 6px; padding: 0px; vertical-align: baseline;">
<span style="font-family: "times" , "times new roman" , serif;">Keywords</span></h2>
<ul class="keyword" id="kwd0005" style="border: 0px; color: #2e2e2e; font-size: 16px; line-height: 23px; list-style: none; margin: 0px 0px 15px; padding: 0px; vertical-align: baseline;"><span style="font-family: "times" , "times new roman" , serif;">
<li class="svKeywords" id="kw0005" style="border: 0px; display: inline; margin: 0px; padding: 0px; vertical-align: baseline;"><span id="" style="border: 0px; margin: 0px; padding: 0px; vertical-align: baseline;">Nirschl surgical technique</span>; </li>
<li class="svKeywords" id="kw0010" style="border: 0px; display: inline; margin: 0px; padding: 0px; vertical-align: baseline;"><span id="" style="border: 0px; margin: 0px; padding: 0px; vertical-align: baseline;">Platelet rich plasma (PRP)</span>; </li>
<li class="svKeywords" id="kw0015" style="border: 0px; display: inline; margin: 0px; padding: 0px; vertical-align: baseline;">Chronic elbow tendinosis</li>
</span></ul>
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<br />Unknownnoreply@blogger.com2tag:blogger.com,1999:blog-26321597.post-42433622489199681892016-01-03T14:40:00.000-08:002016-01-03T14:40:01.924-08:00Biologic Orthopedic Society passes 5000 Member Mark<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhKNff4SkBrZ8sUDhR5TV4TX0vrmmFsBVJTQVcax9CIm_k7Pv1_jDkCmkRNmLSz5OxVrsgWjau5G6T_hggBzjRMc_Hhj_pl2GnOh0MCr7EiZS6yzeAJjE2HxIRUHGTI2YWpgMKt/s1600/BOS+5000.png" imageanchor="1"><img border="0" height="93" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhKNff4SkBrZ8sUDhR5TV4TX0vrmmFsBVJTQVcax9CIm_k7Pv1_jDkCmkRNmLSz5OxVrsgWjau5G6T_hggBzjRMc_Hhj_pl2GnOh0MCr7EiZS6yzeAJjE2HxIRUHGTI2YWpgMKt/s400/BOS+5000.png" width="400" /></a><br />
<br />
The <a href="https://www.linkedin.com/groups/4464752" target="_blank">Biologic Orthopedic Society</a> (BOS) recently passed the 5000 member mark. (<a href="https://www.linkedin.com/groups/4464752" target="_blank">Link to join</a>)<br />
<br />
The society was started in 2012 with the simple goal of connecting what I thought would be 200-300 people interested in biologic orthopedics. The group has dramatically exceeded those expectations. We now have members from six continents spanning many different orthopedic, musculoskeletal and business disciplines. As 2016 unfolds, the BOS will hopefully continue to grow and help advance this rapidly expanding field.<br />
<br />
<a href="http://www.allanmishra.com/" target="_blank">AM</a>Unknownnoreply@blogger.com4tag:blogger.com,1999:blog-26321597.post-47955783713570038902015-12-19T15:35:00.000-08:002015-12-22T08:50:08.393-08:00Brave Thinking<div class="MsoNormal">
<b style="mso-bidi-font-weight: normal;"><span style="font-size: large;">Seek the distance and
difficult shore.<span style="mso-spacerun: yes;"> </span></span><o:p></o:p></b></div>
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<br /></div>
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<tr><td class="tr-caption" style="text-align: center;">Earth "Rising" from NASA</td></tr>
</tbody></table>
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The data suggests almost no chance of reaching the distant destination.<span style="mso-spacerun: yes;"> </span>Think bravely and embark in spite of the
data.<span style="mso-spacerun: yes;"> </span>As you progress on your faithful
journey, you will become more efficient with your efforts.<span style="mso-spacerun: yes;"> </span>Productive currents could also land you
ashore beyond your previously imagined target. <span style="mso-spacerun: yes;"> </span>By setting insanely lofty goals, you
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can accomplish.<span style="mso-spacerun: yes;"> </span>Yes, you may not achieve
your stated objective.<span style="mso-spacerun: yes;"> </span>You may be
disappointed, discouraged or even collapse.<span style="mso-spacerun: yes;">
</span>Only by failing, however, will you know the limits of what you can accomplish.
<span style="mso-spacerun: yes;"> </span><br />
<br />
<br />
<br />
<br />
<table cellpadding="0" cellspacing="0" class="tr-caption-container" style="float: left; margin-right: 1em; text-align: left;"><tbody>
<tr><td style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiSYOIPZ5lfbW84iFgm9swCKrTjA8xL95Go2jfsK1NM0aDMfajQvL2Xzj6VGyqPNbL4UDWLbLa5AWVsxN2_cIW3TyBD6YoUsaP72qd1YXYSLlmx9mBedrqHZzHhyBmMZVje-1v2/s1600/spacex.png" imageanchor="1" style="clear: left; margin-bottom: 1em; margin-left: auto; margin-right: auto;"><img border="0" height="168" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiSYOIPZ5lfbW84iFgm9swCKrTjA8xL95Go2jfsK1NM0aDMfajQvL2Xzj6VGyqPNbL4UDWLbLa5AWVsxN2_cIW3TyBD6YoUsaP72qd1YXYSLlmx9mBedrqHZzHhyBmMZVje-1v2/s200/spacex.png" width="200" /></a></td></tr>
<tr><td class="tr-caption" style="text-align: center;">Landing of SpaceX Falcon 9 Rocket</td></tr>
</tbody></table>
<br />
<b>Thoreau stated it well:<span style="mso-spacerun: yes;"> </span></b><o:p></o:p></div>
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<o:p></o:p></div>
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<b><span style="font-family: "Times New Roman"; font-size: 12.0pt; mso-ansi-language: EN-US; mso-bidi-language: AR-SA; mso-fareast-font-family: "MS 明朝"; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-fareast;">“In the long run men (and women) hit only what they aim at. Therefore, though they should fail
immediately, they had better aim at something high”. </span></b><br />
<b><span style="font-family: "Times New Roman"; font-size: 12.0pt; mso-ansi-language: EN-US; mso-bidi-language: AR-SA; mso-fareast-font-family: "MS 明朝"; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-fareast;"><br /></span></b>
<b><span style="font-family: "Times New Roman"; font-size: 12.0pt; mso-ansi-language: EN-US; mso-bidi-language: AR-SA; mso-fareast-font-family: "MS 明朝"; mso-fareast-language: EN-US; mso-fareast-theme-font: minor-fareast;">#HeroThinking</span></b><!--EndFragment--><br />
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<br />Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-26321597.post-65935961509032542202015-09-19T11:34:00.001-07:002015-09-19T11:42:13.677-07:00Tiger Woods Spine SurgeryTiger Woods just had surgery on his back for the second time and will be out for a indefinite amount of time. Apparently, something was pinching on a nerve and causing him significant pain. <br />
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(<a href="http://espn.go.com/golf/story/_/id/13687070/tiger-woods-undergoes-another-back-surgery" target="_blank">ESPN Story</a>)<br />
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Below is a video of my own spine surgery from several years ago. Thankfully, I have done very well. <br />
Let's hope his second surgery will allow Tiger to return in 2016 to an elite level of play. <br />
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<iframe allowfullscreen="" frameborder="0" height="315" src="https://www.youtube.com/embed/W_9YaOLcFAg" width="560"></iframe>
<a href="http://www.allanmishra.com/" target="_blank"><br /></a>
<a href="http://www.allanmishra.com/" target="_blank">AM</a><br />
<a href="http://www.totaltendon.com/" target="_blank">TotalTendon</a><br />
<br />Unknownnoreply@blogger.com1tag:blogger.com,1999:blog-26321597.post-43120566183604062022015-08-01T20:26:00.002-07:002015-08-08T18:15:52.132-07:00Respect Your Future Health (#BodyIRA)<b>Body Individual Retirement Account (BodyIRA)</b><br />
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When I was in medical school and about 22 years old, an erudite 50-year old professor made a claim that <b>the warranty on the human body wears out at age 45. </b>As I fidgeted in my uncomfortable back row seat in a packed classroom, I thought to myself---what an old man. I couldn't even contemplate what it would feel like to be 45 or 50. I can now attest to the validity of my professor's claim because I have seen friends, family members and patients endure unexpected medical issues in their 40s. <b>I have a suggestion: Open a BodyIRA.</b><br />
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<span style="background-color: white;"><span style="font-family: Times, Times New Roman, serif;">What is a BodyIRA? It's not a financial investment, but an investment in good health practices. <b>Think of a BodyIRA as a bridge to your future health.</b> Just like a retirement savings account, a BodyIRA is a gift you give to yourself, by taking care of yourself now so you can be healthy far into the future. And just like retirement savings, the sooner you begin to contribute to your BodyIRA, the more benefits you will reap later in life.</span></span><br />
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<b><a href="https://www.linkedin.com/grp/home?gid=6988505&report%2Esuccess=7GcSc9MenMD5-zxa-kN_TToM-x5janvu_HMEw0LwSaLTiMXToFk2hhLiKanEipLCLCi2aHOMY2Q0YQnTDIu0oJnh-x5wKBYTHQ" target="_blank">Request to join the BodyIRA LinkedIn Group</a> </b><br />
(Goal: share ideas about health and fitness)<br />
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<b><u>Four Starter Recommendations for your BodyIRA</u></b><br />
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<b>1. Maintain or work toward your ideal body weight (Keep a daily record of your weight)</b><br />
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<b>2. Stretch your hamstrings and develop strong legs (<a href="http://www.powerknee.com/" target="_blank">See the PowerKnee Program</a>)</b><br />
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<b>3. Focus on your posture (Sit up and Stand up straight)</b><br />
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<b>4. Get 7-8 hours of sleep per night or more</b><br />
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<b>Consistent exercise, a healthy diet coupled with stable sleep patterns are like buying index funds for your future health.</b> In our twenties, we are told to begin contributing to a retirement savings plan like a 401k or an individual retirement account (IRA). Put away a little money each month and you will see it grow into millions of dollars over the course of the next 40 years. We need to emulate that sage advice and translate it to our health.<br />
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<b>BodyIRA leads to dramatic dividends later.</b> One profound example is bone density in women. Women in their teens and early twenties are building their bony framework. In their thirties and beyond, they will make withdrawals from this bone bank. If they do not deposit enough early on, they pay a heavy price later in the form of osteoporosis. <br />
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<b>We have all heard this type of advice before but let's make it actionable.</b> <span style="background-color: white; font-family: Times, 'Times New Roman', serif;">Don't just take it from a friend or a medical professional. Take it directly from your future self. What would your ten-years-older self have to say to your current self? If that older you limped in the door and looked at what you were doing, he or she might just scream at you to get your butt off the couch, stop bingeing on Netflix and get some exercise. </span>Begin by committing to writing down your weight daily and doing some simple leg exercises. (See <a href="http://www.powerknee.com/" target="_blank">PowerKnee Program</a>) If you can initiate the habit of contributing to your BodyIRA for two weeks, you will experience some immediate benefits and also be contributing to your future health.<br />
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Importantly, it's never too late to open a BodyIRA. Don't worry if you are in your 30s, 40s, 50s or even beyond 60, you can still work toward a better physical and mental situation. Much like a "catch up" contribution to your 401k or IRA, if you start later, you will need to pay more. Also, as we age, the body requires more maintenance. Don't get mad about it and neglect your aging engine and wheels. <b> Respect your future health and start your own BodyIRA today. You will reap the priceless reward of future well-being. </b><br />
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<a href="http://www.allanmishra.com/" target="_blank">AM</a><br />
<a href="http://www.totaltendon.com/" target="_blank">TotalTendon</a><br />
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<br />Unknownnoreply@blogger.com12tag:blogger.com,1999:blog-26321597.post-18020255322341101122015-06-11T06:00:00.000-07:002016-03-31T06:50:12.458-07:00Will Biologics Revolutionize Musculoskeletal Care?<div class="separator" style="clear: both; text-align: center;">
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEi4rqZTiOhgteK3LWa7ZTON5FC21OIKd7-VqKwKLkobT495dvn670E7VnQ86QCpUHUGtCbnkVPKHIY1vzklCoazrJoBqNgiymZuyp7bGBRhXKMyePb5tpbT8gBBxOV8C75dhVTi/s1600/MSK+Cost.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="204" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEi4rqZTiOhgteK3LWa7ZTON5FC21OIKd7-VqKwKLkobT495dvn670E7VnQ86QCpUHUGtCbnkVPKHIY1vzklCoazrJoBqNgiymZuyp7bGBRhXKMyePb5tpbT8gBBxOV8C75dhVTi/s320/MSK+Cost.jpg" width="320" /></a></div>
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<span style="font-family: "helvetica neue" , "arial" , "helvetica" , sans-serif;">The economic costs of musculoskeletal care in the United States is approaching $800 billion </span><span style="font-family: "helvetica neue" , "arial" , "helvetica" , sans-serif;">or about 5.7% of annual GDP. (</span><a href="http://www.boneandjointburden.org/" style="font-family: 'Helvetica Neue', Arial, Helvetica, sans-serif;" target="_blank">Ref</a><span style="font-family: "helvetica neue" , "arial" , "helvetica" , sans-serif;">) These costs are expected to increase significantly as our population ages. This is clearly not a sustainable path. A recent article published by the American Academy of Orthopedic Surgeons (AAOS) suggests the "early evidence is promising" for biologics to revolutionize musculoskeletal care. (</span><a href="http://www.aaos.org/news/aaosnow/jun15/clinical1.asp" style="font-family: 'Helvetica Neue', Arial, Helvetica, sans-serif;" target="_blank"><b>AAOS Article in full</b></a><span style="font-family: "helvetica neue" , "arial" , "helvetica" , sans-serif;">)</span><br />
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEg5hW7rxNmVJcX3gzSRM2jl6_x-SG2LVvXvqHMvhL_o94jA9sE_7RLNpFYBWvAHNWjBH_eSN9zgVhBUltxL00CLSRQGuevjrM8Gr1Rcc1o9dUm9YhoDqJCjsmYbdS0gl0hIZsbK/s1600/Google+Trends+2.png" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><span style="font-family: "helvetica neue" , "arial" , "helvetica" , sans-serif;"><img border="0" height="227" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEg5hW7rxNmVJcX3gzSRM2jl6_x-SG2LVvXvqHMvhL_o94jA9sE_7RLNpFYBWvAHNWjBH_eSN9zgVhBUltxL00CLSRQGuevjrM8Gr1Rcc1o9dUm9YhoDqJCjsmYbdS0gl0hIZsbK/s320/Google+Trends+2.png" width="320" /></span></a></div>
<span style="font-family: "helvetica neue" , "arial" , "helvetica" , sans-serif;">Biologic therapies represent a rapidly evolving frontier similar to arthroscopy in the 1970s and 1980s. There will always be a need for continued research and development but the data supporting treatments such as platelet rich plasma (PRP) and stem cell treatments for tendinopathy and arthritis is increasing significantly. PRP is now a recognized treatment for chronic tennis elbow that has been shown to be better than surgery. (<a href="http://plateletrichplasma.blogspot.com/2016/01/platelet-rich-plasma-beats-surgery-for.html" target="_blank">See Ref</a>) The number of PRP articles on PubMed now is over 8000 and the Google Trends for PRP is rising rapidly. (See Graph)</span><br />
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<span style="font-family: "helvetica neue" , "arial" , "helvetica" , sans-serif;">Biologic orthopedic procedures are in the process of revolutionizing the options available for patients for difficult problems such as arthritis. <span style="background-color: white;">It is an exciting time to execute on these point-of-care biologic treatments. Continued progress will demand hard work and innovation by elite motivated teams in order to produce transformative outcomes for patients.</span></span><br />
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<span style="background-color: white; font-family: "times" , "times new roman" , serif;"><br /></span>
<span style="background-color: white; font-family: "times" , "times new roman" , serif;"><a href="http://www.allanmishra.com/" target="_blank"><b>AM</b></a></span><br />
<span style="background-color: white; font-family: "times" , "times new roman" , serif;"><a href="http://www.totaltendon.com/" target="_blank"><b>TotalTendon</b></a></span><br />
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<br />Unknownnoreply@blogger.com5tag:blogger.com,1999:blog-26321597.post-13802783646641478422015-04-11T11:52:00.000-07:002015-04-11T11:52:09.381-07:00The Apple Watch and MedicineI just tried on the new Apple Watch and was immediately impressed. <br />
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I put the 42 mm space gray Apple Sport version with an aluminum case and black strap on first. The display was crisp despite the bright sunlight that was streaming into Palo Alto store. The Apple employee tapped the watch twice and it went into demo mode. It scrolled through a bunch of its functions including various displays, messaging options and of course the heart rate monitor. I was fascinated and ready to run out the store with my new toy. I also tried on the Apple Watch version with the stainless steel case and the Milanese band. (See video below). That version was a little heavier than the sport version but the band was simply sublime. It has a magnetic clasp and can be easily adjusted. It felt like a high end watch you could wear out to a fancy event.<br />
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<iframe allowfullscreen="" frameborder="0" height="315" src="https://www.youtube.com/embed/726H1THjv_A" width="560"></iframe>
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Both of these watches are expensive ($399 and $699). Are they worth it? I am not sure just yet. I am in the process of trying to figure out if I will order one. You can't buy in the store and it is now back ordered online until June or perhaps even July. I do want to replace my chest strap heart rate monitor that is hooked to my iPhone. Glacing down at my watch would be a much simpler way to figure out if I am at my target zone especially during a bike ride. I can also see how it would be useful for patients who need to closely monitor their heart rates during exercise because of its simplicity. <br />
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Let me know what you think if you have tried it on and if the watch will have any specific medical or exercise applications that will be significantly useful.<br />
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<a href="http://www.allanmishra.com/" target="_blank">AM</a><br />
<a href="http://www.totaltendon.com/" target="_blank">TotalTendon</a>Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-26321597.post-10569142917341581482015-04-01T19:56:00.000-07:002015-04-03T10:57:34.749-07:00Top 7 Life Lessons from Steve Martin<div class="separator" style="clear: both; text-align: center;">
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A few years back I was very lucky and blessed to play poker
with Steve Martin in Las Vegas with my friend Phil Hellmuth. The three of us also had a fantastic dinner
discussion that has made an enduring impression on my life. </div>
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Mr. Martin is a superb writer, musician, actor, and producer.<span style="mso-spacerun: yes;"> </span>He also recently hosted the Saturday Night
Live 40th reunion show and expertly managed the egos of dozens of elite stars
from music, TV and the movies. We can all learn from his sublime approach to
work and life.<span style="mso-spacerun: yes;"> </span><o:p></o:p></div>
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<b style="mso-bidi-font-weight: normal;"><u>7 Life Lessons from American icon Steve Martin<o:p></o:p></u></b></div>
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<b style="mso-bidi-font-weight: normal;">1. “Be so good, they
can’t ignore you”<o:p></o:p></b></div>
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<b style="mso-bidi-font-weight: normal;">2. “It’s pain that
changes our lives”</b><span style="mso-spacerun: yes;"> </span><o:p></o:p></div>
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From <i style="mso-bidi-font-style: normal;">Shopgirl<o:p></o:p></i></div>
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<b style="mso-bidi-font-weight: normal;">3. “Thankfully,
persistence is a great substitute for talent”<o:p></o:p></b></div>
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<i style="mso-bidi-font-style: normal;">From Born Standing Up,
A Comic’s Life<o:p></o:p></i></div>
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<b style="mso-bidi-font-weight: normal;"><span style="color: #131313; mso-bidi-font-family: Georgia;">4. “I thought yesterday was the
first day of the rest of my life but it turns out today is.”<o:p></o:p></span></b></div>
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<b style="mso-bidi-font-weight: normal;"><span style="color: #131313; mso-bidi-font-family: Georgia;">5. “I have found that-- just as
in real life--imagination sometimes has to stand in for experience.” <o:p></o:p></span></b></div>
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<span style="color: #131313; mso-bidi-font-family: Georgia;">From,
</span><a href="http://www.goodreads.com/work/quotes/11176080"><i><span style="color: #535502; mso-bidi-font-family: Georgia; text-decoration: none; text-underline: none;">An Object Of Beauty</span></i></a><span style="color: #131313; mso-bidi-font-family: Georgia;"><o:p></o:p></span></div>
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<b style="mso-bidi-font-weight: normal;"><span style="color: #131313; mso-bidi-font-family: Georgia;"><span style="mso-spacerun: yes;"> 6. </span>“I just believe that the interesting time in a
career is pre-success, what shaped things, how did you get to this point?” <o:p></o:p></span></b></div>
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<span style="color: #131313; mso-bidi-font-family: Georgia;">From,
</span><a href="http://www.goodreads.com/work/quotes/3315115"><i><span style="color: #535502; mso-bidi-font-family: Georgia; text-decoration: none; text-underline: none;">Born Standing Up: A Comic's Life</span></i></a><span style="color: #131313; mso-bidi-font-family: Georgia;"><o:p></o:p></span></div>
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<b style="mso-bidi-font-weight: normal;"><span style="color: #131313; mso-bidi-font-family: Georgia;">7. “Were they beautiful? We
were all beautiful. We were in our twenties.”<o:p></o:p></span></b></div>
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<span style="color: #131313; mso-bidi-font-family: Georgia;">Thank
you Mr. Martin for sharing your immense talent with the world. Please share his wisdom with your network.<o:p></o:p></span></div>
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<br /></div>
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<span style="color: #131313; mso-bidi-font-family: Georgia;"><a href="http://www.allanmishra.com/" target="_blank">AM</a><o:p></o:p></span></div>
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<br /></div>
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<span style="color: #131313; mso-bidi-font-family: Georgia;">Ref:<span style="mso-spacerun: yes;"> </span>http://www.goodreads.com/author/show/7103.Steve_Martin<o:p></o:p></span></div>
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<span style="color: #131313; mso-bidi-font-family: Georgia;">Visit
the site for more Steve Martin quotes<o:p></o:p></span></div>
Unknownnoreply@blogger.com1tag:blogger.com,1999:blog-26321597.post-83400370795447786372015-03-21T12:30:00.002-07:002019-09-22T15:01:38.996-07:00PowerKnee Program<b><a href="http://daretobevital.com/" target="_blank">DareToBeVital.com</a> </b> Knee pain is a very common problem. There are many potential remedies but one that is often ignored is diet and exercise. This led me to develop the PowerKnee Program. It is a simple set of exercises that may help improve the pain associated with a variety of knee problems including arthritis. The exercises help address quadriceps strength, hamstring flexibility and overall lower extremity fitness. This program can be found at <b><a href="http://powerknee.com/">PowerKnee.com</a>. </b>Pass on the link to your friends and colleagues.<br />
<br />
<b><u>POWERKNEE PROGRAM (See Videos below)</u></b><br />
<b>1. QuadCrunch (TM): </b> Perform a set of 3 hold for 5 seconds, 3 times per day<br />
<b>2. Hamstring Stretch:</b> Perform a set of 3, hold for 5 seconds, 3 times per day<br />
<b>3. Exercise Bike: </b> Ride for 30 minutes, 3 times per week, Record calories<br />
<br />
Also, maintain or work toward your ideal body weight. Losing even a small amount of weight may improve your knee pain and function. <br />
<br />
Get going today on the <a href="http://www.powerknee.com/" target="_blank"><b>#PowerKnee</b></a> Program. Pass on the link to your friends and colleagues.<br />
<br />
<span style="background-color: white; font-family: "arial" , "tahoma" , "helvetica" , "freesans" , sans-serif; font-size: 12px; line-height: 16px;">Text "KneePain" to 22828 for a FREE newsletter to help with Knee Pain</span><br />
<br />
<iframe allowfullscreen="" frameborder="0" height="315" src="https://www.youtube.com/embed/EREKD3bFwCc" width="560"></iframe>
<br />
<br />
<iframe allowfullscreen="" frameborder="0" height="315" src="https://www.youtube.com/embed/j5GOzvMOyiU" width="560"></iframe>
<br />
<br />
<iframe allowfullscreen="" frameborder="0" height="315" src="https://www.youtube.com/embed/lK7Y2SS5WJc" width="560"></iframe>
<span style="font-family: "arial" , "helvetica" , sans-serif; font-size: x-small;"><b><br /></b></span>
<span style="font-family: "arial" , "helvetica" , sans-serif; font-size: x-small;"><b><br /></b></span><br />
<span style="font-family: "arial" , "helvetica" , sans-serif; font-size: x-small;"><b style="font-family: "Trebuchet MS"; font-size: medium;"><a href="http://daretobevital.com/" target="_blank">DareToBeVital.com</a></b></span><br />
<br />
<span style="font-family: "arial" , "helvetica" , sans-serif; font-size: x-small;"><b>DO NOT BEGIN ANY EXERCISE PROGRAM WITHOUT FIRST CHECKING WITH YOUR DOCTOR.</b></span><br />
<b><span style="font-family: "arial" , "helvetica" , sans-serif; font-size: x-small;">THIS WEBSITE IS FOR INFORMATION PURPOSES ONLY. CONSULT WITH HEALTHCARE PROFESSIONALS TO DETERMINE IF IT IS RIGHT FOR YOU.</span></b><br />
<b><span style="font-family: "arial" , "helvetica" , sans-serif; font-size: x-small;"><br /></span></b>
<b><span style="font-family: "arial" , "helvetica" , sans-serif; font-size: x-small;"><a href="http://www.allanmishra.com/" target="_blank">AM</a></span></b><br />
<b><span style="font-family: "arial" , "helvetica" , sans-serif; font-size: x-small;"><a href="http://www.totaltendon.com/" target="_blank">TotalTendon</a></span></b>Unknownnoreply@blogger.com1tag:blogger.com,1999:blog-26321597.post-2437658724858353422015-03-10T10:02:00.000-07:002015-03-10T10:02:55.373-07:00PRP enhances healing after Achilles Tendon Rupture <br />
<table cellpadding="0" cellspacing="0" class="tr-caption-container" style="float: left; margin-right: 1em; text-align: left;"><tbody>
<tr><td style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEitNgtVJcWl84p44ypFYDNutKrTiB0xdPgOQD825MA5sFwpDitTJ2LuSwuNQ3RYMbQbvdvo6p-6Tvgl2MTxMxWoVvGJc9aLfIK6xCuRQX1vwV8E7yr2e9FEK6YGcNyv_Nq8uX96/s1600/Achilles+Repair+PRP.png" imageanchor="1" style="clear: left; margin-bottom: 1em; margin-left: auto; margin-right: auto;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEitNgtVJcWl84p44ypFYDNutKrTiB0xdPgOQD825MA5sFwpDitTJ2LuSwuNQ3RYMbQbvdvo6p-6Tvgl2MTxMxWoVvGJc9aLfIK6xCuRQX1vwV8E7yr2e9FEK6YGcNyv_Nq8uX96/s1600/Achilles+Repair+PRP.png" height="279" width="320" /></a></td></tr>
<tr><td class="tr-caption" style="text-align: center;">PRP being added to an Achilles Tendon Repair</td></tr>
</tbody></table>
If you rupture your Achilles tendon, new data suggests platelet rich plasma can enhance the healing. In an abstract published by the journal <a href="http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(15)60334-8.pdf" target="_blank">Lancet</a>, researchers from England discussed how they treated patients who had ruptured their Achilles with either PRP or a placebo. Six weeks later, they biopsied the healing tendons under ultrasonic guidance. In the study, they found improved cell content, better tendon fiber structure and more normal collagen (type 1) in the tendons treated with PRP. The study included 20 patients (10 PRP, 10 Control) and is the first investigation in humans showing the significant value of using PRP to help treat Achilles tendon ruptures. Of course, more data will be needed to confirm these important findings. For years, I have been adding PRP to my achilles tendon repairs and if I ever rupture my own, I will certainly request that PRP is included in the treatment protocol.<br />
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Unknownnoreply@blogger.com2tag:blogger.com,1999:blog-26321597.post-52569252091211031012015-02-27T06:02:00.001-08:002015-02-27T07:55:47.261-08:00Top Five Lessons from my Visit to Tesla Motors<table cellpadding="0" cellspacing="0" class="tr-caption-container" style="float: left; margin-right: 1em; text-align: left;"><tbody>
<tr><td style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjQhhec9aVU2pXI08nytslqw1xGrDXCNsHXnhmSe3NfilCj-osMPsKVQypE4o4Cxidly5imzKMNq-tcGVRtvk1qGl0EDbuIv41BjGo7Na_vcqtZy09kI7uEZwfLMGXFkDKaljMV/s1600/Tesla+HQ.jpg" imageanchor="1" style="clear: left; margin-bottom: 1em; margin-left: auto; margin-right: auto;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjQhhec9aVU2pXI08nytslqw1xGrDXCNsHXnhmSe3NfilCj-osMPsKVQypE4o4Cxidly5imzKMNq-tcGVRtvk1qGl0EDbuIv41BjGo7Na_vcqtZy09kI7uEZwfLMGXFkDKaljMV/s1600/Tesla+HQ.jpg" height="164" width="200" /></a></td></tr>
<tr><td class="tr-caption" style="text-align: center;"><b>Tesla's Headquarters</b></td></tr>
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I recently visited Tesla's headquarters in Palo Alto, California with my daughter and
came away truly inspired. Tesla’s
headquarters is located adjacent to the Stanford University campus in rolling
green hills just south of the linear accelerator and the venture capital lined
Sand Hill Road. I am lucky to know one
of Tesla’s elite engineers who was very gracious and gave my daughter and me a
superb insider tour.</div>
<o:p></o:p><br />
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<b><u>Here are my top five lessons from the visit:</u></b></div>
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<b style="mso-bidi-font-weight: normal;">Dream Monumental
Dreams<o:p></o:p></b></div>
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<b style="mso-bidi-font-weight: normal;">Hire Amazing Talent<o:p></o:p></b></div>
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<b style="mso-bidi-font-weight: normal;">Stick to your Vision<o:p></o:p></b></div>
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<b style="mso-bidi-font-weight: normal;">Innovate and Execute<o:p></o:p></b></div>
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<b style="mso-bidi-font-weight: normal;">Create stellar products and have fun<o:p></o:p></b></div>
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Tesla is America at its best.<span style="mso-spacerun: yes;"> </span>It is a visionary company that is trying to
change the world with its electric vehicles and products.<span style="mso-spacerun: yes;"> </span>Their newest car, the Model S is not a leaf sized
lawn mower.<span style="mso-spacerun: yes;"> </span>It is a super charged sexy sports
car that makes you fell like you are in the Jetsons’ world when you drive
it.<span style="mso-spacerun: yes;"> </span>(More about that later)<o:p></o:p></div>
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<tr><td class="tr-caption" style="text-align: center;"><b>The Model S from Tesla</b></td></tr>
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Tesla is a place of monumental dreams and superior talent
that is sticking to its vision of producing electric cars that are better than
their gasoline counterparts. They have
already achieved some of that dream by winning Motor Trend’s car of the year in
2013. (<a href="http://www.motortrend.com/oftheyear/car/1301_2013_motor_trend_car_of_the_year_tesla_model_s/#__federated=1" target="_blank">Reference</a>) The company is also working on a battery that
could serve as an axillary power supply for your home and perhaps even support the entire electrical
grid. (<a href="http://www.washingtonpost.com/blogs/the-switch/wp/2015/02/12/this-new-tesla-battery-will-power-your-home-and-maybe-the-electric-grid-too/" target="_blank">Reference</a>)</div>
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The people I saw working there have an infectious sense of
purpose that is missing in my world of biomedical research and medicine.<span style="mso-spacerun: yes;"> </span>They work together without walls or even
cubicles.<span style="mso-spacerun: yes;"> </span>This promotes a sense of a
united mission.<span style="mso-spacerun: yes;"> </span>Those of us who work in
research and healthcare are too often siloed in our specific specialities.<span style="mso-spacerun: yes;"> </span>We almost never cross over and discuss our
problems with colleagues outside of our world.<span style="mso-spacerun: yes;">
</span>We need to emulate companies such as Tesla.<span style="mso-spacerun: yes;"> </span>Their way of executing in the electric car business
could lead to breakthroughs in medicine that could be transformative.<span style="mso-spacerun: yes;"> </span>I also think Nicola Tesla would be very proud
of how his name is being used.<o:p></o:p></div>
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And by the way, I had a chance to test drive a Model S Tesla
at the end of my visit.<span style="mso-spacerun: yes;"> </span>It was like a magnetic
bullet train on wheels.<span style="mso-spacerun: yes;"> </span>I punched the
accelerator and it felt like we were taking off for Mars.<span style="mso-spacerun: yes;"> </span><span style="mso-spacerun: yes;"> </span>#Awesome<o:p></o:p></div>
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<br /></div>
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<a href="http://www.allanmishra.com/" target="_blank">AM</a></div>
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<br /></div>
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<a href="http://www.totaltendon.com/" target="_blank">TotalTendon</a></div>
<!-- Blogger automated replacement: "https://images-blogger-opensocial.googleusercontent.com/gadgets/proxy?url=http%3A%2F%2F2.bp.blogspot.com%2F-Ljbn7ACD0YI%2FVPB0qKu7kUI%2FAAAAAAAABnI%2Fml-6vpco2PM%2Fs1600%2FTesla%252BCar.jpg&container=blogger&gadget=a&rewriteMime=image%2F*" with "https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjJVe7dyu2cV03pPXyMqa1ADTE1JdNZ5pCYQZaEg6qco0BvJZ4Yd7HDRSVNqi6MJ5FpFjHSQ-gpGE4JU-9PXE659RGXbLVPTHq9-55s6u-NjmDc148afMzRmFMmeejXnX6bN6eN/s1600/Tesla+Car.jpg" -->Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-26321597.post-12001515758012998842015-01-25T20:19:00.000-08:002015-01-25T20:19:51.182-08:00$87 Billion Dollars for Total Knee Replacements by 2030?<b>We have an epidemic of knee arthritis in the United States with over 10 million affected Americans </b>(<a href="http://www.businessgrouphealth.org/pub/f31386d4-2354-d714-51b9-1feaa06b262d" target="_blank">Ref</a>). Many treatments are prescribed with variable efficacy for this common problem. When all else fails, knee replacement is often recommended. This procedure is overall highly successful but also expensive. <br />
<br />
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiL80jzduAVSrnsbQupFX84OuEgV2gVnLVfcg943xSBnvOhW4msqmoq2HK26tY5ZlI0hcihZ6u3MsqwRmhyphenhyphen9aWQOYj9JVOqG00qqHP54Su9us_hMJlEC9xMSoNtQJKWxsAjPLaB/s1600/TKA+Projections.png" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiL80jzduAVSrnsbQupFX84OuEgV2gVnLVfcg943xSBnvOhW4msqmoq2HK26tY5ZlI0hcihZ6u3MsqwRmhyphenhyphen9aWQOYj9JVOqG00qqHP54Su9us_hMJlEC9xMSoNtQJKWxsAjPLaB/s1600/TKA+Projections.png" height="280" width="400" /></a>In 2009, the CDC reported the estimated costs of knee replacement in the US to be $28.5 billion dollars (<a href="http://www.cdc.gov/arthritis/basics/osteoarthritis.htm" target="_blank">Ref</a>). Published reports suggest there will be a need for almost 3.5 million knee replacements in the United States by 2030 (<a href="http://www.ncbi.nlm.nih.gov/pubmed/17403800" target="_blank">See paper</a>). At a conservative total cost of $25,000 per surgery, that translates into $87 billion dollars. So, the projections suggest the costs will triple over the next 15 years. <br />
<br />
<b>That is $87 Billion Dollars just in the United States to treat end-stage knee arthritis.</b> That is just the cost of knee replacements. It does not include other surgical or non-operative costs. It also doesn't include treatment of other potentially arthritic joints such as the hip or shoulder. <br />
<br />
We can and should immediately begin an <b>all-in assault against arthritis</b>. <br />
<br />
Patients need to act on the first line of treatment. They can help themselves with a program of diet and exercise. Simple exercises such as the <a href="http://plateletrichplasma.blogspot.com/2014/07/quadcrunch-tm-best-exercise-for-your.html" target="_blank"><b>QuadCrunch</b></a> and <a href="http://plateletrichplasma.blogspot.com/2014/09/powerknee-hamstring-stretch-video.html" target="_blank"><b>Hamstring Stretching</b></a> can be quite helpful. Riding a bike is another way to exercise with arthritic knees. Losing even a small amount of weight can result in less pain and more function.<br />
<br />
The good news is many new treatments are in development to treat this difficult problem. The bad news is the effort is fractionated. It is important to note that knee arthritis is not simply a disease of the cartilage. There is dysfunction in muscle, tendon, ligament, cartilage and bone when a patient has arthritis. A better understanding of the genetic and epigenetic causes of arthritis is also needed. We will need a systematic approach to treating all of the components of the disease in order to be successful.<br />
<br />
On the horizon are a plethora of biologic treatments including <a href="http://www.apexprp.com/" target="_blank">platelet rich plasma</a>, stem cells and even gene therapy. We need to embrace these novel treatments do the hard work that is needed to prove their safety and value. <br />
<br />
A coalition of patients, providers, payers, researchers and industry need to come together and execute on potential treatments and prevention strategies. We cannot afford to continue with the status quo and spend almost $90 Billion Dollars on knee replacements in 2030. <br />
<br />
Please post your comments or suggestions below.<br />
<br />
<a href="http://www.allanmishra.com/" target="_blank">AM</a><br />
<a href="http://www.totaltendon.com/" target="_blank">TotalTendon</a><br />
<br />
<br />
<br />Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-26321597.post-8320585099159623722015-01-04T17:24:00.000-08:002015-01-04T17:24:35.189-08:00Improve how your DNA works by Riding an Exercise Bike<h3>
The Epigenetics of Exercise</h3>
<div>
<a href="http://www.allanmishra.com/" target="_blank">Allan Mishra, MD</a></div>
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<b><br /></b></div>
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEg_3a6lSDfkcgGRvo7yKshyphenhyphen1Trk7wz2JyOZ_7qHVrGS_1tBaF0xjRgQgEerHvqVBadqsxVxgDVcjmqhOPhb3akDBcDYsw2hzoNMzPjaIMOdyXDjbUws3pnWE9CfSPJU6zAxn-28/s1600/DNA.jpg" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEg_3a6lSDfkcgGRvo7yKshyphenhyphen1Trk7wz2JyOZ_7qHVrGS_1tBaF0xjRgQgEerHvqVBadqsxVxgDVcjmqhOPhb3akDBcDYsw2hzoNMzPjaIMOdyXDjbUws3pnWE9CfSPJU6zAxn-28/s1600/DNA.jpg" height="200" width="195" /></a><b style="mso-bidi-font-weight: normal;">You can’t </b><b>change your
DNA but you can change how it works.</b> DNA is the coding program for
all of the enzymes and proteins that make your body function. </div>
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<b style="mso-bidi-font-weight: normal;">Epigenetics is a
rapidly evolving area of science that </b><b>studies how modifications on or around your DNA alter the production of specific molecules.</b> Your DNA is fixed but how it works is
affected by the proteins and chemical groups that surround the famous double helix.<span style="mso-spacerun: yes;"> </span>You can think of
epigenetics as variable signposts on the winding tracks of your DNA that either
suppress or promote specific genes.<span style="mso-spacerun: yes;"> </span>The
proteins and chemical groups have fancy names like a “histone” or a “methyl group”.<span style="mso-spacerun: yes;"> </span>These "epigenetic" markers don’t change your DNA but
rather change how it interprets the underlying genetic code.<span style="mso-spacerun: yes;"> </span>They can turn on or off a section of DNA and
dramatically affect YOU.<span style="mso-spacerun: yes;"> </span>The science is
called “Epigenetics” and in 2015 and beyond, it will alter the way we all approach medicine and wellness. Multiple articles about epigenetics have appeared in <a href="http://content.time.com/time/magazine/article/0,9171,1952313,00.html" target="_blank">Time Magazine</a>, the <a href="http://well.blogs.nytimes.com/2014/12/17/how-exercise-changes-our-dna/?_r=0" target="_blank">New York Times</a> and many other elite publications.<o:p></o:p></div>
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgmLqRi-ygBcBMoAWWQihbvmYRv9Tj3DcXs-IRgL1A683HK_D_FuQ7hS8t2jhUFnHaFSVktUwLFz-GMgu4kwoUQReivwErDpo5ne-yULEKQFOjEfG878AI39Jba3vPzV6fqgWnF/s1600/Screen+Shot+2015-01-02+at+5.14.59+PM.png" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgmLqRi-ygBcBMoAWWQihbvmYRv9Tj3DcXs-IRgL1A683HK_D_FuQ7hS8t2jhUFnHaFSVktUwLFz-GMgu4kwoUQReivwErDpo5ne-yULEKQFOjEfG878AI39Jba3vPzV6fqgWnF/s1600/Screen+Shot+2015-01-02+at+5.14.59+PM.png" height="200" width="161" /></a></div>
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<b>Exercise is one way
you can change how your DNA expresses itself via epigenetics in a positive
fashion.</b> A recently published study required people to ride an exercise bike with one leg for 45 minutes four times per week for three months. Before and after the exercise trial, the subjects
had a muscle biopsy of both legs. The researchers found "health enhancing adaptations" were induced by the "physiologic stimulus" of riding an exercise bike via epigenetic mechanisms in the leg that did the pedaling but not in the one that did nothing. (Ref: <a href="http://www.ncbi.nlm.nih.gov/pubmed/25484259" target="_blank">Lindholm et al 2014</a>) The
results are meaningful for anyone who wants to stay in shape and be active. Importantly, the inherited proportion of physical performance has been shown to be about 50%. Therefore, about 50% of overall physical performance is dependent upon training and lifestyle. (Ref: <a href="http://www.ncbi.nlm.nih.gov/pubmed/23329609" target="_blank">Ehlert etal 2013</a>) This means that we are at least partially in control of how our bodies work and perform. We can't blame all of our health problems on bad genes. </div>
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Exercise has also been found to have positive effects on the central nervous system, the cardiovascular system, the aging process, the prevention of type 2 diabetes and the prevention of cancer all via epigenetic mechanisms. (Ref: <a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Ntantasis-Stathopoulos" target="_blank">Ntanasis-Stathopoulos et al, 2013</a>)</div>
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So, dust off the exercise bike in the garage, make time in your schedule to get to the gym, or join <a href="https://www.soul-cycle.com/info/" target="_blank">Soul-Cycle</a> in 2015. <br />
<b><br /></b>
Specific immediate action items: Consider starting your exercise routine with <a href="http://plateletrichplasma.blogspot.com/2014/07/quadcrunch-tm-best-exercise-for-your.html" target="_blank"><b>QuadCrunches</b></a> and <a href="http://plateletrichplasma.blogspot.com/2014/09/powerknee-hamstring-stretch-video.html" target="_blank"><b>Hamstring Stretches</b>.</a> They are simple exercises that can be done anywhere<b>. </b>For the bike, try 20-30 minutes 3 times per week with moderate resistance.<br />
<b><br /></b><b>Remember, exercise can literally change how your DNA functions and potentially save your life.</b></div>
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<br />
<a href="http://www.allanmishra.com/" target="_blank">AM</a></div>
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<br /></div>
<div class="MsoNormal">
<a href="http://www.totaltendon.com/" target="_blank">TotalTendon</a><br />
<br />
<b>ALWAYS consult your own physicians before beginning any exercise program.</b></div>
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<!--EndFragment-->Unknownnoreply@blogger.com4tag:blogger.com,1999:blog-26321597.post-18021185685165721322014-12-12T09:46:00.002-08:002014-12-12T09:52:06.922-08:00Using a 3D Printer to Make a Knee Meniscus<div>
<br /></div>
<div>
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhrFrLYWmydbWEYDBByYakm_bg6Ga8JEM19oJ9_JFuF3v1V0lPxNLKj-6uNNx9WGyH9pYF2jYEDobNQgRcopfUZDRa6o_i421SukFR4-iV_9G2aLPseaCdJD0L6KImMCpc3UU-S/s1600/Screen+Shot+2014-12-12+at+9.42.46+AM.png" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhrFrLYWmydbWEYDBByYakm_bg6Ga8JEM19oJ9_JFuF3v1V0lPxNLKj-6uNNx9WGyH9pYF2jYEDobNQgRcopfUZDRa6o_i421SukFR4-iV_9G2aLPseaCdJD0L6KImMCpc3UU-S/s1600/Screen+Shot+2014-12-12+at+9.42.46+AM.png" height="141" width="320" /></a>Meniscus cartilage is the cushioning tissue between the femur and tibia bones of the knee. Millions of Americans each year tear this cartilage. Loss of the meniscus tissue can lead to arthritis.</div>
<div>
<br /></div>
<div>
In this novel approach, researchers in New York are using a 3D Printer to create a new meniscus. They have studied in sheep so far with success. In the future, it may be possible to use an MRI scan with a meniscus tear to help program a 3D printer to make you a new meniscus. Treatment in human patients is not yet available but this is quite an intriguing possibility for the future.</div>
<div>
<br /></div>
<iframe allowfullscreen="" frameborder="0" height="315" src="//www.youtube.com/embed/yTDK88G2ed0" width="560"></iframe><br />
<br />
<b>Reference</b><br />
<span class="article-overline" style="border: 0px; color: #333333; display: block; font-family: 'Lucida Grande', arial, helvetica, sans-serif; font-size: 13px; font-weight: bold; line-height: 16px; margin: 0px 0px 0.3em; outline-style: none; padding: 0px; text-transform: uppercase; vertical-align: baseline;">TISSUE ENGINEERING</span><br />
<div class="article abstract-view " itemprop="articleBody" style="border: 0px; color: #333333; font-family: 'Lucida Grande', arial, helvetica, sans-serif; font-size: 13px; line-height: 16px; margin: 0px; outline-style: none; padding: 0px; vertical-align: baseline;">
<span class="highwire-journal-article-marker-start" style="border: 0px; font-family: inherit; font-size: inherit; font-style: inherit; line-height: inherit; margin: 0px; outline-style: none; padding: 0px; text-align: inherit; vertical-align: baseline;"></span><br />
<h1 id="article-title-1" itemprop="headline" style="border: 0px; font-size: 15px; font-style: inherit; line-height: inherit; margin: 0px 0px 2px; outline-style: none; padding: 0px; vertical-align: baseline;">
Protein-releasing polymeric scaffolds induce fibrochondrocytic differentiation of endogenous cells for knee meniscus regeneration in sheep</h1>
<div class="contributors" style="border: 0px; font-family: inherit; font-size: inherit; font-style: inherit; line-height: inherit; margin: 0px; outline-style: none; padding: 0px; vertical-align: baseline;">
<ol class="contributor-list" id="contrib-group-1" style="border: 0px; font-family: inherit; font-size: inherit; font-style: inherit; font-weight: bold; line-height: inherit; list-style: none; margin: 0px; outline-style: none; padding: 0px; vertical-align: baseline;">
<li class="contributor" id="contrib-1" itemprop="author" itemscope="itemscope" itemtype="http://schema.org/Person" style="border: 0px; display: inline; font-family: inherit; font-size: inherit; font-style: inherit; font-weight: inherit; line-height: 1.7; margin: 0px; outline-style: none; padding: 0px; text-align: left; vertical-align: baseline;"><span class="name" itemprop="name" style="border: 0px; font-family: inherit; font-size: inherit; font-style: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline-style: none; padding: 0px; text-align: inherit; vertical-align: baseline;"><a class="name-search" href="http://stm.sciencemag.org/search?author1=Chang+H.+Lee&sortspec=date&submit=Submit" style="border: 0px; color: #333333; font-family: inherit; font-size: inherit; font-style: inherit; line-height: inherit; margin: 0px; outline-style: none; padding: 0px; text-align: inherit; text-decoration: none; vertical-align: 0px; white-space: nowrap;">Chang H. Lee</a></span><a class="xref-aff" href="http://stm.sciencemag.org/content/6/266/266ra171.abstract#aff-1" id="xref-aff-1-1" style="border: 0px; color: #2e6d8f; font-family: inherit; font-size: 0.85em; font-style: inherit; font-weight: normal; line-height: 0; margin: 0px; outline-style: none; padding: 0px; text-align: inherit; text-decoration: none; vertical-align: super;"><span style="border: 0px; font-family: inherit; font-size: 1em; font-style: inherit; line-height: 0; margin: 0px; outline-style: none; padding: 0px; text-align: inherit; vertical-align: 0em;">1</span></a>, </li>
<li class="contributor" id="contrib-2" itemprop="author" itemscope="itemscope" itemtype="http://schema.org/Person" style="border: 0px; display: inline; font-family: inherit; font-size: inherit; font-style: inherit; font-weight: inherit; line-height: 1.7; margin: 0px; outline-style: none; padding: 0px; text-align: left; vertical-align: baseline;"><span class="name" itemprop="name" style="border: 0px; font-family: inherit; font-size: inherit; font-style: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline-style: none; padding: 0px; text-align: inherit; vertical-align: baseline;"><a class="name-search" href="http://stm.sciencemag.org/search?author1=Scott+A.+Rodeo&sortspec=date&submit=Submit" style="border: 0px; color: #333333; font-family: inherit; font-size: inherit; font-style: inherit; line-height: inherit; margin: 0px; outline-style: none; padding: 0px; text-align: inherit; text-decoration: none; vertical-align: 0px; white-space: nowrap;">Scott A. Rodeo</a></span><a class="xref-aff" href="http://stm.sciencemag.org/content/6/266/266ra171.abstract#aff-2" id="xref-aff-2-1" style="border: 0px; color: #2e6d8f; font-family: inherit; font-size: 0.85em; font-style: inherit; font-weight: normal; line-height: 0; margin: 0px; outline-style: none; padding: 0px; text-align: inherit; text-decoration: none; vertical-align: super;"><span style="border: 0px; font-family: inherit; font-size: 1em; font-style: inherit; line-height: 0; margin: 0px; outline-style: none; padding: 0px; text-align: inherit; vertical-align: 0em;">2</span></a>, </li>
<li class="contributor" id="contrib-3" itemprop="author" itemscope="itemscope" itemtype="http://schema.org/Person" style="border: 0px; display: inline; font-family: inherit; font-size: inherit; font-style: inherit; font-weight: inherit; line-height: 1.7; margin: 0px; outline-style: none; padding: 0px; text-align: left; vertical-align: baseline;"><span class="name" itemprop="name" style="border: 0px; font-family: inherit; font-size: inherit; font-style: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline-style: none; padding: 0px; text-align: inherit; vertical-align: baseline;"><a class="name-search" href="http://stm.sciencemag.org/search?author1=Lisa+Ann+Fortier&sortspec=date&submit=Submit" style="border: 0px; color: #333333; font-family: inherit; font-size: inherit; font-style: inherit; line-height: inherit; margin: 0px; outline-style: none; padding: 0px; text-align: inherit; text-decoration: none; vertical-align: 0px; white-space: nowrap;">Lisa Ann Fortier</a></span><a class="xref-aff" href="http://stm.sciencemag.org/content/6/266/266ra171.abstract#aff-3" id="xref-aff-3-1" style="border: 0px; color: #2e6d8f; font-family: inherit; font-size: 0.85em; font-style: inherit; font-weight: normal; line-height: 0; margin: 0px; outline-style: none; padding: 0px; text-align: inherit; text-decoration: none; vertical-align: super;"><span style="border: 0px; font-family: inherit; font-size: 1em; font-style: inherit; line-height: 0; margin: 0px; outline-style: none; padding: 0px; text-align: inherit; vertical-align: 0em;">3</span></a>, </li>
<li class="contributor" id="contrib-4" itemprop="author" itemscope="itemscope" itemtype="http://schema.org/Person" style="border: 0px; display: inline; font-family: inherit; font-size: inherit; font-style: inherit; font-weight: inherit; line-height: 1.7; margin: 0px; outline-style: none; padding: 0px; text-align: left; vertical-align: baseline;"><span class="name" itemprop="name" style="border: 0px; font-family: inherit; font-size: inherit; font-style: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline-style: none; padding: 0px; text-align: inherit; vertical-align: baseline;"><a class="name-search" href="http://stm.sciencemag.org/search?author1=Chuanyong+Lu&sortspec=date&submit=Submit" style="border: 0px; color: #333333; font-family: inherit; font-size: inherit; font-style: inherit; line-height: inherit; margin: 0px; outline-style: none; padding: 0px; text-align: inherit; text-decoration: none; vertical-align: 0px; white-space: nowrap;">Chuanyong Lu</a></span><a class="xref-aff" href="http://stm.sciencemag.org/content/6/266/266ra171.abstract#aff-1" id="xref-aff-1-2" style="border: 0px; color: #2e6d8f; font-family: inherit; font-size: 0.85em; font-style: inherit; font-weight: normal; line-height: 0; margin: 0px; outline-style: none; padding: 0px; text-align: inherit; text-decoration: none; vertical-align: super;"><span style="border: 0px; font-family: inherit; font-size: 1em; font-style: inherit; line-height: 0; margin: 0px; outline-style: none; padding: 0px; text-align: inherit; vertical-align: 0em;">1</span></a>, </li>
<li class="contributor" id="contrib-5" itemprop="author" itemscope="itemscope" itemtype="http://schema.org/Person" style="border: 0px; display: inline; font-family: inherit; font-size: inherit; font-style: inherit; font-weight: inherit; line-height: 1.7; margin: 0px; outline-style: none; padding: 0px; text-align: left; vertical-align: baseline;"><span class="name" itemprop="name" style="border: 0px; font-family: inherit; font-size: inherit; font-style: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline-style: none; padding: 0px; text-align: inherit; vertical-align: baseline;"><a class="name-search" href="http://stm.sciencemag.org/search?author1=Cevat+Erisken&sortspec=date&submit=Submit" style="border: 0px; color: #333333; font-family: inherit; font-size: inherit; font-style: inherit; line-height: inherit; margin: 0px; outline-style: none; padding: 0px; text-align: inherit; text-decoration: none; vertical-align: 0px; white-space: nowrap;">Cevat Erisken</a></span><a class="xref-aff" href="http://stm.sciencemag.org/content/6/266/266ra171.abstract#aff-1" id="xref-aff-1-3" style="border: 0px; color: #2e6d8f; font-family: inherit; font-size: 0.85em; font-style: inherit; font-weight: normal; line-height: 0; margin: 0px; outline-style: none; padding: 0px; text-align: inherit; text-decoration: none; vertical-align: super;"><span style="border: 0px; font-family: inherit; font-size: 1em; font-style: inherit; line-height: 0; margin: 0px; outline-style: none; padding: 0px; text-align: inherit; vertical-align: 0em;">1</span></a> and </li>
<li class="last" id="contrib-6" style="border: 0px; display: inline; font-family: inherit; font-size: inherit; font-style: inherit; font-weight: inherit; line-height: 1.7; margin: 0px; outline-style: none; padding: 0px; text-align: left; vertical-align: baseline;"><span class="name" style="border: 0px; font-family: inherit; font-size: inherit; font-style: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline-style: none; padding: 0px; text-align: inherit; vertical-align: baseline;"><a class="name-search" href="http://stm.sciencemag.org/search?author1=Jeremy+J.+Mao&sortspec=date&submit=Submit" style="border: 0px; color: #333333; font-family: inherit; font-size: inherit; font-style: inherit; line-height: inherit; margin: 0px; outline-style: none; padding: 0px; text-align: inherit; text-decoration: none; vertical-align: 0px; white-space: nowrap;">Jeremy J. Mao</a></span><a class="xref-aff" href="http://stm.sciencemag.org/content/6/266/266ra171.abstract#aff-1" id="xref-aff-1-4" style="border: 0px; color: #2e6d8f; font-family: inherit; font-size: 0.85em; font-style: inherit; font-weight: normal; line-height: 0; margin: 0px; outline-style: none; padding: 0px; text-align: inherit; text-decoration: none; vertical-align: super;"><span style="border: 0px; font-family: inherit; font-size: 1em; font-style: inherit; line-height: 0; margin: 0px; outline-style: none; padding: 0px; text-align: inherit; vertical-align: 0em;">1</span></a><span class="xref-sep" style="border: 0px; font-family: inherit; font-size: inherit; font-style: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline-style: none; padding: 0px; text-align: inherit; vertical-align: super;">,</span><a class="xref-corresp" href="http://stm.sciencemag.org/content/6/266/266ra171.abstract#corresp-1" id="xref-corresp-1-1" style="border: 0px; color: #2e6d8f; font-family: inherit; font-size: 0.85em; font-style: inherit; font-weight: normal; line-height: 0; margin: 0px; outline-style: none; padding: 0px; text-align: inherit; text-decoration: none; vertical-align: super;">*</a></li>
</ol>
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<a href="http://newsroom.cumc.columbia.edu/blog/2014/12/10/3d-printed-meniscus/" target="_blank">Read More</a><br />
<br />
<a href="http://stm.sciencemag.org/content/6/266/266ra171.abstract" target="_blank">Read the scientific abstract</a><br />
<br />
<a href="http://www.allanmishra.com/" target="_blank">AM</a><br />
<a href="http://www.totaltendon.com/" target="_blank">TotalTendon</a>Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-26321597.post-58522763605411643032014-12-09T20:40:00.000-08:002014-12-09T20:40:09.495-08:00Microfracture Surgery Jadaveon ClowneyThe Houston Texans' Jadeveon Clowney recently underwent "microfracture" surgery on his ailing right knee. (<a href="http://espn.go.com/nfl/story/_/id/12006927/jadeveon-clowney-houston-texans-microfracture-surgery-9-months" target="_blank">See ESPN report</a>)<br />
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The report suggests the talented Mr. Clowney will be out for 9 months or more. Just what is microfracture surgery and why does it take as long to recovery as it does for a baby to born?<br />
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<table cellpadding="0" cellspacing="0" class="tr-caption-container" style="float: left; margin-right: 1em; text-align: left;"><tbody>
<tr><td style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjZug7Aa9opoP1HEsT40O74VHYJjGRH4BLB5-EDWGsZ8M0QDvNjB290A6zXryMRxGu3Qa22VrIsvG4GycqyaFRNh5iETOnJ7fX_thzTrGU3tiFdZUj7TR6WK7uvKy7GtvZIA08A/s1600/Screen+Shot+2014-12-09+at+8.08.59+PM.png" imageanchor="1" style="clear: left; margin-bottom: 1em; margin-left: auto; margin-right: auto;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjZug7Aa9opoP1HEsT40O74VHYJjGRH4BLB5-EDWGsZ8M0QDvNjB290A6zXryMRxGu3Qa22VrIsvG4GycqyaFRNh5iETOnJ7fX_thzTrGU3tiFdZUj7TR6WK7uvKy7GtvZIA08A/s1600/Screen+Shot+2014-12-09+at+8.08.59+PM.png" height="180" width="200" /></a></td></tr>
<tr><td class="tr-caption" style="text-align: center;">Microfracture Surgery</td></tr>
</tbody></table>
Let's start with the basics. There are two types of cartilage in the knee. The surface cartilage which covers the bone. This is known as articular cartilage and can be thought of a type of cap or covering of the end of the bone. This cartilage is present in any joint. In the knee, there is another type of cartilage, the meniscus cartilage. There are two menisci in the knee--medial (inside) and lateral (outside). When the surface "articular" cartilage is damaged, the knee can become quite painful especially with loading and twisting. Think rushing a passer for example. Similar symptoms can occur when the meniscus is torn. It is often difficult to distinguish between the two in terms of which one is the pain generator.<br />
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Microfracture surgery is an attempt to create a tire patch over a cartilage defect by poking a hole in the end of the bone and creating an access channel to the bone marrow. The bone marrow then leaks out via the holes that are created and forms a clot which over time can help cover the defect. It takes time, many months, for this surgery to work because the "patch" needs to mature. This technique is useful for small defects in the cartilage but hasn't proven to be great for larger defects. We do not know the size of Mr. Clowney's knee cartilage injury. <br />
<br />
Recent evidence suggests that the addition of platelet-rich plasma can enhance microfracture surgery results. This has been shown in <a href="http://www.ncbi.nlm.nih.gov/pubmed/19216642" target="_blank">basic science</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed/23748620" target="_blank">preclinical</a> and now <a href="http://www.ncbi.nlm.nih.gov/pubmed/24292979" target="_blank">clinical studies</a>.<br />
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This type of surgery at such a young age is clearly not a good sign. In the long run, he may require further intervention. Please read the post below for further information about why we need to accelerate our regenerative medicine efforts. Mr. Clowney is one of tens of millions of people worldwide with symptomatic cartilage damage. We need to maximize outcomes of today's surgical techniques and develop new procedures to help keep our athletes and patients in the game.<br />
<a href="http://www.allanmishra.com/" target="_blank"><br /></a>
<a href="http://www.allanmishra.com/" target="_blank">AM</a><br />
<br />
<a href="http://www.totaltendon.com/" target="_blank">TotalTendon</a><br />
<br />
<br />Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-26321597.post-59531105654989458972014-12-07T17:00:00.000-08:002014-12-08T07:24:39.393-08:00Will Kobe Bryant go to Japan to Treat his Knee Arthritis?<div class="MsoNormal">
<h4>
<b style="mso-bidi-font-weight: normal;">Japan Accelerates
Regenerative Medicine with Regulatory Reforms</b></h4>
<h4>
<b style="mso-bidi-font-weight: normal;">Why the United States
Must Follow Their Lead</b></h4>
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<b style="mso-bidi-font-weight: normal;"><a href="http://www.ipetitions.com/petition/regenerative-medicine-reform" target="_blank">Sign the online petition supporting Regenerative Medicine</a><o:p></o:p></b></div>
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiq3pv_s1NgD0ZMdzxtuZzkhVJ0XHb9-WxTSJJg1ZRKTaaUt50fO1c4xHLmO6zte6uHTdislzapSsT6HjJ86K8OKw3anCPlNFv_PvSzW7J4JotbwynnTNVVvRTtG3Kys5Bco2R1/s1600/Screen+Shot+2014-12-06+at+11.47.37+AM.png" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiq3pv_s1NgD0ZMdzxtuZzkhVJ0XHb9-WxTSJJg1ZRKTaaUt50fO1c4xHLmO6zte6uHTdislzapSsT6HjJ86K8OKw3anCPlNFv_PvSzW7J4JotbwynnTNVVvRTtG3Kys5Bco2R1/s1600/Screen+Shot+2014-12-06+at+11.47.37+AM.png" height="320" width="316" /></a></div>
<b>Kobe Bryant</b>, an elite professional athlete from the National
Basketball Association’s Los Angeles Lakers, has gone to Germany multiple times
to be treated with a portion of his own blood for his creaky, arthritic knees. <span style="mso-spacerun: yes;"> </span>The reason why he went to Germany is
simple.<span style="mso-spacerun: yes;"> </span>He wanted to have the best
chance to play at the highest level in the NBA and he had exhausted all his
options in the United States.<span style="mso-spacerun: yes;"> </span><b>He went there to be treated with a component of his own blood that targets the
inflammation associated with knee osteoarthritis.</b><span style="mso-spacerun: yes;"><b> </b> </span>The treatment he received is not approved
here in the United States.<span style="mso-spacerun: yes;"> </span><o:p></o:p></div>
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Will he go to Japan next time to get the most advanced therapy?<span style="mso-spacerun: yes;"> </span>That may happen because in November 2014 <b>Japan enacted legislation creating a new pathway that accelerates the approval process for regenerative
medicine products</b>. We here in the United States need to
figure out how to best accelerate our own regenerative medicine efforts or continue
to watch our elite athletes and other patients seek treatment beyond our
shores.<span style="mso-spacerun: yes;"> </span>Let’s explore why Japan acted
boldly in favor of regenerative medicine.<span style="mso-spacerun: yes;">
</span><o:p></o:p></div>
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A Nobel Prize was awarded to Japanese researcher and former
orthopedic surgeon, <a href="http://www.nobelprize.org/nobel_prizes/medicine/laureates/2012/yamanaka-facts.html" target="_blank">Dr. Shinya Yamanaka</a> in 2012 for his pioneering work on how
to reprogram mature skin cells into pluripotent stem cells.<span style="mso-spacerun: yes;"> </span>His potentially life saving work and the
national pride associated with it helped Japan become a worldwide leader in
stem cell research.<span style="mso-spacerun: yes;"> </span>Importantly, Japan
has also prospectively pursued and passed legislation that will dramatically stimulate
regenerative medicine.<span style="mso-spacerun: yes;"> </span>The country took
a leap into a bright future last week with the implementation of regulatory
reforms directed at accelerating the development of cell-based treatments.<span style="mso-spacerun: yes;"> </span><o:p></o:p></div>
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The new law established a separate pathway for regenerative
medicine products apart from traditional drugs and medical devices. The
regulations also created a system that fosters faster commercialization of
novel biologic products and can lead to time limited approvals for
up to seven years.<span style="mso-spacerun: yes;"> </span>Post market data
analysis will continue to confirm the safety and efficacy of the regenerative
medicine products with the potential to revoke approvals.<span style="mso-spacerun: yes;"> </span><o:p></o:p></div>
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The action by the Japanese government creates the proper equilibrium
between the need for accelerated approvals for cell based therapies that have
established efficacy while ensuring product safety.<span style="mso-spacerun: yes;"> </span>The typical phase one, phase two and phase
three trials for new drugs are not a proper pathway for cell-based therapies
that have highly complex mechanisms of action that may or may not be identified
even with elite preclinical models.<span style="mso-spacerun: yes;"> </span><b>Importantly,
many cell-based products come directly from a patient’s own body and therefore
have a dramatically higher safety profile.<span style="mso-spacerun: yes;">
</span></b><o:p></o:p></div>
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<b>Americans are screaming for new treatments for a variety of
difficult problems such as arthritis, heart disease and diabetes.<span style="mso-spacerun: yes;"> </span>Regenerative medicine and especially cell-based
treatments have a chance to help treat and potentially cure these
problems.<span style="mso-spacerun: yes;"> </span>We need to follow the Japanese
lead and create similar pathways in the United States</b>.<span style="mso-spacerun: yes;"> </span>Last year during a visit to Japan and its PMDA
(the equivalent of the FDA), I was staggered by how engaged they were about
regenerative medicine and receptive they were to understanding how to bring
safe and effective biologic products to their populace. <o:p></o:p></div>
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The United States can learn a great deal from Japan’s enlightened
approach to regenerative medicine.<span style="mso-spacerun: yes;">
</span>Safety of course should be paramount.<span style="mso-spacerun: yes;">
</span>The idea of a conditional, time-limited approval with reimbursement
strikes a perfect chord as we seek better treatments for our patients at more
affordable prices.<span style="mso-spacerun: yes;"> </span>Competition will
arise to obtain approvals based on phase two trials that confirm safety and
show a solid degree of efficacy.<span style="mso-spacerun: yes;">
</span>Importantly, more competition will lead to better options and faster
innovation similar to the computer industry over the last several decades.<span style="mso-spacerun: yes;"> </span><o:p></o:p></div>
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<b>We need to also emulate our Silicon Valley technology
colleagues and call for a Medical Moore’s Law.<span style="mso-spacerun: yes;">
</span>Identify a specific clinical problem, create a novel solution and within five
years double the efficacy and decrease the price by fifty percent. </b><span style="mso-spacerun: yes;"> Data analysis via powerful graphical algorithms should assist with new discoveries and also help with better management of many diseases. </span><br />
<br />
<b>We must seek dramatically higher horizons instead of being
satisfied with iterative improvements. </b><span style="mso-spacerun: yes;"> </span>The Japanese government should be
congratulated for passing regulatory reform and implementing transformative
solutions.<span style="mso-spacerun: yes;"> </span>Sooner, not later, we need to
find ways to execute our own regulatory reforms here in the United States to
help our patients and to remain competitive on the world stage in regenerative
medicine.<o:p></o:p></div>
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<b>Perhaps, then Kobe will be treated in California instead of
Germany or Japan.</b><o:p></o:p><br />
<br /></div>
<div class="MsoNormal">
<a href="http://www.allanmishra.com/" target="_blank"><b>Allan Mishra, MD</b></a></div>
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<b><br /></b>
<b><a href="http://www.totaltendon.com/" target="_blank">TotalTendon</a></b><br />
<br />
<br />
<b style="mso-bidi-font-weight: normal;"><a href="http://www.ipetitions.com/petition/regenerative-medicine-reform" target="_blank">Sign the online petition supporting Regenerative Medicine</a></b><br />
<br />
<br />
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<b>Please post any comments or suggestions about how to safely accelerate regenerative medicine.</b></div>
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<b style="mso-bidi-font-weight: normal;"><span style="font-size: 11.5pt;"><u>References</u><o:p></o:p></span></b></div>
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<span style="font-size: 11.5pt;">(</span><a href="http://www.nobelprize.org/nobel_prizes/medicine/laureates/2012/yamanaka-facts.html"><span style="font-size: 11.5pt;">http://www.nobelprize.org/nobel_prizes/medicine/laureates/2012/yamanaka-facts.html</span></a><span style="font-size: 11.5pt;">)<o:p></o:p></span></div>
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<span style="font-size: 11.5pt;">Accessed 11/30/14<o:p></o:p></span></div>
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<a href="http://www.pmda.go.jp/english/events/2014taiwan_sympo/14_Keynote1.pdf"><span style="font-size: 11.5pt;">http://www.pmda.go.jp/english/events/2014taiwan_sympo/14_Keynote1.pdf</span></a><span style="font-size: 11.5pt;"><o:p></o:p></span></div>
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